2953-41-5Relevant articles and documents
Aziridine-Mediated Ligation at Phenylalanine and Tryptophan Sites
Bajaj, Kiran,Sakhuja, Rajeev
supporting information, p. 1869 - 1874 (2017/08/10)
An efficient approach towards peptide synthesis that allows easy access to variety of small peptides via one-pot aziridine-mediated ligation/desulfurization strategy has been described. The protocol afforded a library of phenylalanine- and tryptophan-containing α-peptides in good yields by regioselective ring-opening of aziridine-3-aryl-2-carboxylates with peptide thioacids, followed by desulfurization.
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Baxendale, Ian R.,Ley, Steven V.,Smith, Christopher D.,Tranmer, Geoffrey K.
, p. 4835 - 4837 (2007/10/03)
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of t
ENANTIOSELECTIVE SYNTHESIS OF PEPTIDES USING (1R)-3-HYDROXY-1,8,8-TRIMETHYL-3-AZABICYCLOOCTANE-2,4-DIONE ((+)-N-HYDROXYCAMPHORIMIDE) AN ACTIVE ESTER GROUP
Takeda, Kazuyoshi,Tsuboyama, Kanoko,Suzuki, Akira,Ogura, Haruo
, p. 2545 - 2548 (2007/10/02)
The enantioselective coupling reaction of N-protected amino acid (+)-N-hydroxycamphorimide esters (-OCamp) with racemic amino acid esters is discussed.The coupling reaction of several amino acids showed high enantioselectivity.Keywords-enantioselective synthesis; (+)-N-hydroxycamphorimide; peptide, active ester; coupling reaction
