49760-60-3Relevant articles and documents
Preparation method of water-soluble florfenicol amino acid salt
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Paragraph 0077-0079; 0102-0103; 0108-0109, (2020/07/21)
The invention discloses a preparation method of a water-soluble florfenicol amino acid ester salt. The method comprises the following steps: using florfenicol and N-Cbz-amino acid as the initial raw materials, carrying out acylating chlorination, esterifi
Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors
Frizler, Maxim,Lohr, Friederike,Furtmann, Norbert,Kl?s, Julia,Gütschow, Michael
supporting information; experimental part, p. 396 - 400 (2011/03/18)
Using the example of cathepsin K, we demonstrate the design of highly potent and selective azadipeptide nitrile inhibitors. A systematic scan with respect to P2 and P3 substituents was carried out. Structural modifications strongly affected the enzyme-inh
A concise route to the proposed structure of lydiamycin B, an antimycobacterial depsipeptide
Li, Wenhua,Gan, Jiangang,Ma, Dawei
supporting information; experimental part, p. 5694 - 5697 (2010/03/01)
[Chemical Equation Presented] The total synthesis of four possible isomers with the proposed structure of antimycobacterial depsipeptide lydiamycin B Is achieved. None of them shows identical NMR data with those reported for natural lydiamycin B, indicati