67865-68-3

Basic information

• Product Name: Z-L-Ala-CHN2
• Synonyms: Z-L-ALA-CHN2
• CAS NO: 67865-68-3
• Molecular Formula: C₁₂H₁₃N₃O₃
• Molecular Weight: 247.24992
• Mol File: 67865-68-3.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Z-L-Ala-CHN2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Ala-CHN2(67865-68-3)
• EPA Substance Registry System: Z-L-Ala-CHN2(67865-68-3)

Safety Data

• Hazardous Substances Data: 67865-68-3(Hazardous Substances Data)

Usage

General Description

Z-L-Ala-CHN2 is a chemical compound that is a derivative of Z-Ala, a modified form of the amino acid alanine. The compound contains a carbonyl group and a nitrogen-containing group, making it a potent inhibitor of proteolytic enzymes. It is commonly used in research settings to study the efficacy of enzyme inhibitors and their potential therapeutic applications. Additionally, Z-L-Ala-CHN2 has been shown to possess anti-inflammatory properties and could potentially be used as a targeted treatment for conditions involving excessive protease activity. Overall, the compound shows promise as a valuable tool for studying enzyme function and as a potential therapeutic agent.

Upstream product

• 186581-53-3 diazomethane 
• 1142-20-7 N-Cbz-Ala 
• 25172-67-2 Z-Ala-O-COO-isoBu 
• 65638-93-9 N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 
• 49760-60-3 N-benzyloxycarbonyl-L-alanyl chloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 152359-72-3 ((S)-3,3-Dihydroxy-1-methyl-2-oxo-propyl)-carbamic acid benzyl ester 
• 128913-34-8 benzyl (S)-(3-oxo-4-(phenylthio)butan-2-yl)carbamate 
• 83460-84-8 methyl (3S)-3-{[(benzyloxy)carbonyl]amino}butanoate 
• 41036-43-5 (3S)-1-chloro-3-(benzyloxycarbonylamino)-2-butanone 
• 83509-88-0 (S)-3-benzyloxycarbonylaminobutyric acid 
• 155149-62-5 (3-bromo-1-(S)-methyl-2-oxopropyl)carbamic acid benzyl ester 
• 1064162-18-0 (3S,4R,1'S)-3-(1-benzyloxycarbonylaminoethyl)-1-(4-methoxybenzyl)-4-phenylazetidin-2-one 

Relevant articles and documents

α-Xanthylmethyl Ketones from α-Diazo ketones

A simple and efficient method to obtain α-xanthylmethyl ketones from α-diazo ketones is described. The reaction proceeds through a protonation/nucleophilic substitution sequence in the presence of p -toluenesulfonic acid and potassium ethyl xanthogenate as the nucleophile. As α-diazo ketones can be readily synthesized from ubiquitous carboxylic acids, a broad variety of xanthates can be obtained, including examples from naturally occurring substrates.

Synthesis of enantiopure free and N-benzyloxycarbonyl-protected 3-substituted homotaurines from naturally occurring amino acids

Enantiopure N-benzyloxycarbonyl-protected and free 3-substituted homotaurines were synthesized from naturally occurring amino acids via N-benzyloxycarbonyl protection, Arndt-Eistert homologation, reduction, esterification with thioacetic acid, and oxidation with performic acid. The current method is a convenient, practical, and salt-free method for the synthesis of enantiopure 3-substituted homotaurine with moderate to good yields.

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.