2953-42-6

Basic information

• Product Name: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester
• CAS NO: 2953-42-6
• Molecular Formula: C25H32N2O5
• Molecular Weight: 440.539
• Mol File: 2953-42-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester(2953-42-6)
• EPA Substance Registry System: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester(2953-42-6)

Safety Data

• Hazardous Substances Data: 2953-42-6(Hazardous Substances Data)

Usage

General Description

L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester is a chemical compound that is a derivative of the amino acids leucine and phenylalanine. It is an ethyl ester, meaning it contains an ethyl group as part of its chemical structure. L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester is commonly used as a building block in peptide synthesis, a process that creates chains of amino acids, known as peptides, which are important biological molecules. It is also used in research and development of new drugs and pharmaceuticals. L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, ethyl ester has potential applications in the field of medicine and biochemistry due to its ability to modify and enhance the properties of peptides and proteins.

Upstream product

• 2743-60-4 L-Leucine ethyl ester 
• 1161-13-3 N-Cbz-L-Phe 
• 58889-73-9 (S)-N-benzyloxycarbonyl-leucine ethyl ester 
• 64-17-5 ethanol 
• 29842-94-2 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate 
• 2743-40-0 L-leucine ethyl ester hydrochloride 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Downstream Products

• 3982-72-7 Cbz-Gly-L-Phe-L-Leu-OEt 
• 3354-31-2 (3S,6S)-3-benzyl-6-isobutylpiperazine-2,5-dione 
• 60566-42-9 L-phenylalanyl-L-leucine ethyl ester 

Relevant articles and documents

Tandem deprotection/coupling for peptide synthesis in water at room temperature

A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz deprotection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded polypeptides containing up to 10 amino acid residues. A broad scope characterizes this new technology. No epimerization has been detected. The associated E Factors, as a measure of "greenness" and known to be extremely high for peptide couplings, have been reduced to less than 10 due to the step-economy and minimal amounts of organic solvent needed for product extraction.

Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion

Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not required an

An improved method for the synthesis of active esters of N-protected amino acids and subsequent synthesis of dipeptides

4-Dimethylaminopyridine-catalyzed reaction of mixed carbonates 3 with N-protected amino acids 4 gave the corresponding active esters 5-9, from which dipeptides 11-18 were synthesized by aminolysis with amino acids 10.