295349-62-1

Basic information

• Product Name: 2-Chloropyridine-4-carboxylic acid tert-butyl ester
• Synonyms: 2-CHLORO-4-PYRIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;2-CHLOROISONICOTINIC ACID T-BUTYL ESTER;2-CHLOROISONICOTINIC ACID TERT-BUTYL ESTER;2-CHLOROPYRIDINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 2-chloropyridine-4-carboxylate;2-CHLORO-4-PYRIDINECARBOXYLIC ACID1,1-D;2-Chloro-4-pyridinecaroboxylic acid methyl ester;2-Chloropyridine-4-carbox...
• CAS NO: 295349-62-1
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66
• Product Categories: Pyridine;Heterocycle-Pyridine series
• Mol File: 295349-62-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 287.439 °C at 760 mmHg
• Flash Point: 127.639 °C
• Appearance: /
• Density: 1.174 g/cm³
• Vapor Pressure: 0.00248mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.27±0.10(Predicted)
• CAS DataBase Reference: 2-Chloropyridine-4-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropyridine-4-carboxylic acid tert-butyl ester(295349-62-1)
• EPA Substance Registry System: 2-Chloropyridine-4-carboxylic acid tert-butyl ester(295349-62-1)

Safety Data

• Hazardous Substances Data: 295349-62-1(Hazardous Substances Data)

Usage

General Description

2-Chloropyridine-4-carboxylic acid tert-butyl ester is a chemical compound commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is a white crystalline powder that is soluble in organic solvents such as acetone and ethanol. 2-Chloropyridine-4-carboxylic acid tert-butyl ester has a molecular formula of C11H13ClN2O2 and a molecular weight of 234.68 g/mol. It is also known by the trade name Boc-2-chloro-4-picolinic acid. The tert-butyl ester group provides increased stability and protection to the carboxylic acid functionality, making it a versatile intermediate in organic synthesis.

InChI:InChI=1/C10H12ClNO2/c1-10(2,3)14-9(13)7-4-5-12-8(11)6-7/h4-6H,1-3H3

Upstream product

• 6313-54-8 2-chloroisonicotinic acid, 
• 24424-99-5 di-tert-butyl dicarbonate 
• 65287-34-5 2-chloropyridine-4-carbonyl chloride 
• 865-47-4 potassium tert-butylate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 67098-46-8 O-tert-butyl-N,N-diisopropyl-isourea 

Downstream Products

• 295349-63-2 tert-butyl 2-morpholinopyridine-4-carboxylate 
• 1338990-46-7 tert-butyl 2-aminopyridine-4-carboxylate 
• 1312770-56-1 tert-butyl 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)propyl]isonicotinate 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 3: From thiophenes to pyridines

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Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4- diazepane-2,5-diones as human chymase inhibitors using structure-based drug design

A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5- diones were explored as human chymase inhibitors using structure-based drug design according to the X-ray cocrystal structure of chymase and compound 1. The optimization focused on

PTERIDINES AND THEIR USE AS AGROCHEMICALS

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