297183-00-7

Basic information

• Product Name: (S)-2-fluoro-3-phenylpropionic acid
• Synonyms: (S)-2-fluoro-3-phenylpropionic acid
• CAS NO: 297183-00-7
• Molecular Weight: 168.168
• Mol File: 297183-00-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-2-fluoro-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-fluoro-3-phenylpropionic acid(297183-00-7)
• EPA Substance Registry System: (S)-2-fluoro-3-phenylpropionic acid(297183-00-7)

Safety Data

• Hazardous Substances Data: 297183-00-7(Hazardous Substances Data)

Upstream product

• 147410-59-1 (E)-2-fluoro-3-phenylprop-2-en-1-ol 
• 826-08-4 2-fluoro 3-phenyl prop-2-ene 1-ol (Z) 
• 141022-95-9 (2S)-2-fluoro-3-phenylpropan-1-ol 
• 350-90-3 (Z/E)-2-fluoro-3-phenylprop-2-enoic acid 
• 104-53-0 3-phenyl-propionaldehyde 
• 458-69-5 3-phenylpropanoic acid fluoride 
• 457-45-4 (±)-2-fluoro-3-phenylpropanoic acid 
• 63-91-2 L-phenylalanine 

Downstream Products

• 1190832-66-6 C₁₅H₁₅FN₂O 

Relevant articles and documents

Synthetic Methods and Reactions. Part 106. Suppression of Anchimerically Assisted Rearrangement Products in the Synthesis of α-Fluorocarboxylic Acids from α-Amino Acids with 48:52 (w/w) Hydrogen Fluoride/Pyridine

Anchimerically assisted rearrangement, observed in the fluorination of some α-amino acids with 70:30 (w/w) hydrogen fluoride/pyridine (by weight) in the presence of NaNO2, is substantially or fully suppressed by using the less acidic reagent 48:52 (w/w) hydrogen fluoride/pyridine.

Asymmetric synthesis of 1,2-fluorohydrin: Iridium catalyzed hydrogenation of fluorinated allylic alcohol

We have developed a simple protocol for the preparation of 1,2-fluorohydrin by asymmetric hydrogenation of fluorinated allylic alcohols using an efficient azabicyclo thiazole-phosphine iridium complex. The iridium-catalyzed asymmetric synthesis of chiral 1,2-fluorohydrin molecules was carried out at ambient temperature with operational simplicity, and scalability. This method was compatible with various aromatic, aliphatic, and heterocyclic fluorinated compounds as well as a variety of polyfluorinated compounds, providing the corresponding products in excellent yields and enantioselectivities. This journal is

Enantioselective protonation of α-hetero carboxylic acid-derived ketene disilyl acetals under chiral ionic Bronsted acid catalysis

Highly enantioselective protonation of α-halo and alkoxy carboxylic acid-derived ketene disilyl acetals is achieved by using P-spiro chiral diaminodioxaphosphonium barfate as a Bronsted acid catalyst, where the enantiofacial discrimination by the catalyst mainly stems from the recognition of the electronic difference between two substituents on the ketene disilyl acetal.