29768-42-1Relevant articles and documents
Quinoline Alkaloids. Part 20. Synthesis of Ptelefolone and O-Methylribaline. Ring Closure of Epoxides of 3-Prenylquinolones
Gaston, John L.,Grundon, Michael F.
, p. 2294 - 2299 (2007/10/02)
2-(1-Hydroxy-1-methylethyl)-6,8-dimethoxy-9-methyl-2,3-dihydrofuroquindiolin-4(9H)-one (5a) and its 8-monomethoxy-analogue O-methylribaline (5d) were prepared from 3-prenylquinolones.Reaction of the N-methyl-4-quinolone (5a) with triphenyl phosphite dichloride gave ptelefolone (9) and the asymmetric synthesis of the alkaloid was explored.Ring closure of epoxides of 3-prenylquinolones in basic and non-basic media is discussed.