6639-61-8

Basic information

• Product Name: N-(2,4-dimethoxyphenyl)formamide
• CAS NO: 6639-61-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.1885
• Mol File: 6639-61-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 382.8°C at 760 mmHg
• Flash Point: 185.3°C
• Density: 1.174g/cm³
• Vapor Pressure: 4.59E-06mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: N-(2,4-dimethoxyphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dimethoxyphenyl)formamide(6639-61-8)
• EPA Substance Registry System: N-(2,4-dimethoxyphenyl)formamide(6639-61-8)

Safety Data

• Hazardous Substances Data: 6639-61-8(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 2735-04-8 2,4-Dimethoxyaniline 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 29768-42-1 2,4-dimethoxy-N,N-dimethylaniline 
• 76030-55-2 (2,4-dimethoxyphenyl)methanamine 
• 1984-21-0 1-isocyano-2,4-dimethoxybenzene 
• 588708-20-7 N-acetyl-N-(4-methoxybenzyl)-α,α-diethylglycine 2,4-dimethoxyphenyl amide 
• 588708-24-1 N-acetyl-N-(4-methoxybenzyl)-α,α-dipropylglycine 2,4-dimethoxyphenyl amide 
• 588708-29-6 N-acetyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine 2,4-dimethoxyphenyl amide 
• 1414857-32-1 C₂₆H₂₂N₄O₅ 
• 54150-76-4 N-(2,4-Dimethoxy-phenyl)-thioformamide 

Relevant articles and documents

Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming

Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chemistry-based probe strategy. Erianin potently inhibited the enzymatic activity of PC, which mediated the anticancer effect of erianin in human hepatocellular carcinoma (HCC). Erianin modulated cancer-related gene expression and induced changes in metabolic intermediates. Moreover, erianin promotes mitochondrial oxidative stress and inhibits glycolysis, leading to insufficient energy required for cell proliferation. Analysis of 14 natural analogs of erianin showed that some compounds exhibited potent inhibitory effects on PC. These results suggest that PC is a cellular target of erianin and reveal the unrecognized function of PC in HCC tumorigenesis; erianin along with its analogs warrants further development as a novel therapeutic strategy for the treatment of HCC.

Multicomponent cascade cycloaddition involving tropone, allenoate, and isocyanide: A rapid access to a 7,6,5-fused tricyclic skeleton

Multicomponent cascade cycloaddition of tropone, allenoate, and isocyanide has been disclosed. This method allows for the rapid construction of a highly unusual tricyclic skeleton in an efficient manner. The proposed transformation proceeds through [8 + 2 + 1] cycloaddition, [1,5]-H shift, and cyclization followed by an alkoxy group migration process.

Efficient one-pot synthesis of unsymmetrical gold(I) N-heterocyclic carbene complexes and their use as catalysts

Eleven different gold(I) complexes of new NHC ligands were prepared in excellent yield, demonstrating the versatility of the new route to NHC complexes. While the influence of electronically different ligands on the synthesis of the catalysts was small, the catalytic activities of the products differed significantly.