1984-21-0

Basic information

• Product Name: Benzene, 1-isocyano-2,4-dimethoxy- (9CI)
• Synonyms: Benzene, 1-isocyano-2,4-dimethoxy- (9CI)
• CAS NO: 1984-21-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17326
• Product Categories: ISONITRITE
• Mol File: 1984-21-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 67-68 °C
• Appearance: /
• CAS DataBase Reference: Benzene, 1-isocyano-2,4-dimethoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyano-2,4-dimethoxy- (9CI)(1984-21-0)
• EPA Substance Registry System: Benzene, 1-isocyano-2,4-dimethoxy- (9CI)(1984-21-0)

Safety Data

• Hazardous Substances Data: 1984-21-0(Hazardous Substances Data)

Usage

General Description

Benzene, 1-isocyano-2,4-dimethoxy- (9CI) is a chemical compound that features a benzene ring with two methoxy (CH3O-) groups and an isocyano (NCO) group attached to it. It is characterized by its aromatic and reactive properties, which make it useful in various chemical reactions and processes. This chemical is commonly used in organic synthesis and as a building block for the production of pharmaceuticals, dyes, and other fine chemicals. However, it is important to handle benzene, 1-isocyano-2,4-dimethoxy- (9CI) with caution, as it is toxic and can pose health risks if not properly managed and used in controlled environments.

Upstream product

• 64-18-6 formic acid 
• 2735-04-8 2,4-Dimethoxyaniline 
• 6639-61-8 N-(2,4-dimethoxyphenyl)formamide 

Downstream Products

• 4107-65-7 2,4-dimethoxybenzonitrile 
• 84370-87-6 2,4-dimethoxyphenyl isocyanate 
• 588708-20-7 N-acetyl-N-(4-methoxybenzyl)-α,α-diethylglycine 2,4-dimethoxyphenyl amide 
• 588708-24-1 N-acetyl-N-(4-methoxybenzyl)-α,α-dipropylglycine 2,4-dimethoxyphenyl amide 
• 588708-29-6 N-acetyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine 2,4-dimethoxyphenyl amide 
• 1356412-68-4 ((2,4-dimethoxyphenyl)isocyano)gold(I) chloride 
• 1376615-58-5 C₂₃H₂₁FN₂O₆ 
• 1414857-32-1 C₂₆H₂₂N₄O₅ 
• 164290-83-9 N-(2,4-dimethoxyphenyl)benzamide 

Relevant articles and documents

Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming

Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chemistry-based probe strategy. Erianin potently inhibited the enzymatic activity of PC, which mediated the anticancer effect of erianin in human hepatocellular carcinoma (HCC). Erianin modulated cancer-related gene expression and induced changes in metabolic intermediates. Moreover, erianin promotes mitochondrial oxidative stress and inhibits glycolysis, leading to insufficient energy required for cell proliferation. Analysis of 14 natural analogs of erianin showed that some compounds exhibited potent inhibitory effects on PC. These results suggest that PC is a cellular target of erianin and reveal the unrecognized function of PC in HCC tumorigenesis; erianin along with its analogs warrants further development as a novel therapeutic strategy for the treatment of HCC.

Efficient one-pot synthesis of unsymmetrical gold(I) N-heterocyclic carbene complexes and their use as catalysts

Eleven different gold(I) complexes of new NHC ligands were prepared in excellent yield, demonstrating the versatility of the new route to NHC complexes. While the influence of electronically different ligands on the synthesis of the catalysts was small, the catalytic activities of the products differed significantly.

A copper(I) isonitrile complex as a heterogeneous catalyst for azide-alkyne cycloaddition in water

A structurally well-defined copper(I) isonitrile complex is shown to be an efficient, heterogeneous catalyst for the Huisgen azide-alkyne 1,3-dipolar cycloaddition under mild conditions in water. Notably, this catalyst can also be utilized in a three-component reaction of halides, sodium azide and alkynes to form 1,4-disubstituted 1,2,3-triazoles in high yields. Furthermore, it can be readily recovered by precipitation and filtration and recycled for at least five runs without significant loss of activity.(Figure Presented)