29848-59-7

Basic information

• Product Name: 1-BROMO-3-(DIFLUOROMETHYL)BENZENE
• Synonyms: 1-BROMO-3-(DIFLUOROMETHYL)BENZENE;BENZENE, 1-BROMO-3-(DIFLUOROMETHYL)-;3-Bromobenzalfluoride97%;1-Bromo-3-(difluoromethyl)
• CAS NO: 29848-59-7
• Molecular Formula: C₇H₅BrF₂
• Molecular Weight: 207.02
• Mol File: 29848-59-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 197.7 °C at 760 mmHg
• Flash Point: 73.4 °C
• Appearance: /
• Density: 1.549 g/cm³
• Vapor Pressure: 0.526mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BROMO-3-(DIFLUOROMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-(DIFLUOROMETHYL)BENZENE(29848-59-7)
• EPA Substance Registry System: 1-BROMO-3-(DIFLUOROMETHYL)BENZENE(29848-59-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 29848-59-7(Hazardous Substances Data)

Usage

General Description

1-Bromo-3-(difluoromethyl)benzene is an organic compound consisting of a benzene ring with a bromine atom at position 1 and a difluoromethyl group at position 3. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is a colorless liquid with a high boiling point, making it useful in high-temperature reactions. It is also used as a building block in the production of materials such as dyes and polymers. However, it is important to handle this compound with caution as it is flammable and may cause skin and eye irritation upon contact.

InChI:InChI=1/C7H5BrF2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,7H

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 368-99-0 3-difluoromethyl-phenylamine 
• 403-25-8 1-(difluoromethyl)-3-nitrobenzene 
• 619-28-3 m-nitrobenzylidene chloride 
• 3429-52-5 2,2,3-trimethyl-2-silabutane 
• 591-18-4 1-Bromo-3-iodobenzene 

Downstream Products

• 197145-32-7 (2RS,3RS)-3-(3-difluoromethyl-phenyl)-1-dimethylamino-2-methyl-pentan-3-ol hydrochloride 
• 945004-44-4 3-(difluoromethyl)benzaldehyde 
• 1242446-34-9 methyl 8-(3-(difluoromethyl)phenyl)quinoline-2-carboxylate 
• 1245623-20-4 Ethyl amino[3-(difluoromethyl)phenyl]acetate 
• 627525-89-7 2-(3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1354286-56-8 N-(5-(3-(difluoromethyl)phenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine 

Relevant articles and documents

5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY

The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

NOVEL BENZYLAMINO SUBSTITUTED QUINAZOLINES AND DERIVATIVES AS SOS1 INHIBITORS

The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.