29886-67-7

Basic information

• Product Name: 4-(THIOPHEN-3-YL)PHENOL 97
• Synonyms: 4-(THIOPHEN-3-YL)PHENOL 97;4-(Thiophen-3-yl)phenol 97%
• CAS NO: 29886-67-7
• Molecular Formula: C₁₀H₈OS
• Molecular Weight: 176.238
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiophenes
• Mol File: 29886-67-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 194-198 °C(lit.)
• Boiling Point: 276.8°C at 760 mmHg
• Flash Point: 121.2°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 0.00279mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 4-(THIOPHEN-3-YL)PHENOL 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(THIOPHEN-3-YL)PHENOL 97(29886-67-7)
• EPA Substance Registry System: 4-(THIOPHEN-3-YL)PHENOL 97(29886-67-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 29886-67-7(Hazardous Substances Data)

Usage

General Description

4-(Thiophen-3-yl)phenol 97 is a chemical compound with the molecular formula C12H9OS. It is a pale yellow solid with a molecular weight of 203.26 g/mol. This chemical is commonly used as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. It has been shown to exhibit antioxidant and anti-inflammatory properties, making it a potential candidate for drug development. Additionally, 4-(Thiophen-3-yl)phenol 97 is also used as a reagent in organic synthesis and as a starting material for the production of other specialty chemicals. It is important to handle this chemical with care and use appropriate safety measures, as it may pose potential health hazards if mishandled.

InChI:InChI=1/C10H8OS/c11-10-3-1-8(2-4-10)9-5-6-12-7-9/h1-7,11H

Upstream product

• 82437-75-0 3-(4-methoxy-phenyl)-thiophene 
• 6165-69-1 Thien-3-ylboronic acid 
• 106-41-2 4-bromo-phenol 
• 30068-21-4 2-(4-methoxyphenyl)-1-methyl-2-propanol 
• 51431-73-3 1-(but-2-en-2-yl)-4-methoxybenzene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 540-38-5 p-Iodophenol 

Downstream Products

• 164399-48-8 2,3-epoxy-4-(3-thienyl)-phenoxypropane 
• 329261-98-5 4-(2-bromo-thiophen-3-yl)phenol 
• 329262-02-4 4-(2-{2-[2-(4-[2,2']bithiophenyl-3-yl-phenoxy)-ethoxy]-ethoxy}-ethoxy)-benzaldehyde 
• 929917-85-1 (S)-2-[4-(4-thiophen-3-yl-phenoxy)-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 929918-40-1 (R)-2-[4-(4-Thiophen-3-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 929918-41-2 (R)-2-[4-(4-thiophen-2-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1196485-58-1 4-[4-(4-thiophen-3-yl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1262545-31-2 4,5-[4-(thiophen-3-yl)-phenoxy]-phthalonitrile 
• 1330616-37-9 C₁₆H₁₉BrOS 
• 1330616-42-6 2-bromo-3-(4-(ω-bromo)hexyloxyphenyl)thiophene 

Relevant articles and documents

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK

A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.

Preparing method of aromatic nitrile or alkenyl nitrile compound

The invention discloses a preparing method of an aromatic nitrile or alkenyl nitrile compound. The preparing method comprises the following step that under protection of inert gas, an aryl or heteroaryl sulphonate compound shown in a formula II or an alkenyl sulphonate compound shown in a formula IV and a cyanation reagent are subjected to a cross-coupling reaction as is shown below in a solvent under the condition of the presence of a nickel complex, metal zinc and an additive to obtain the aromatic nitrile or alkenyl nitrile compound, wherein 4-dimethylamiopryidine (DMAP) is adopted as the additive, and zinc cyanide is adopted as the cyanation reagent. By means of the preparing method, cyanation of aryl sulphonate, heteroaryl sulphonate or alkenyl sulphonate can be simply and efficientlyachieved with a cheap catalysis system; moreover, the functional group compatibility and substrate universality are good, and a better application prospect and higher using value are provided for achieving industrial synthesis of the aromatic nitrile or alkenyl nitrile compound.

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.