299215-69-3Relevant articles and documents
A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles
Olivera, Roberto,SanMartin, Raul,Dominguez, Esther,Solans, Xabier,Urtiaga, Miren Karmele,Arriortua, Maria Isabel
, p. 6398 - 6411 (2007/10/03)
A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.