300678-35-7

Basic information

• Product Name: (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol
• Synonyms: (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol
• CAS NO: 300678-35-7
• Molecular Weight: 304.343
• Mol File: 300678-35-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol(300678-35-7)
• EPA Substance Registry System: (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol(300678-35-7)

Safety Data

• Hazardous Substances Data: 300678-35-7(Hazardous Substances Data)

Upstream product

• 38153-27-4 (2E)-3-(4-O-benzyloxy-3-methoxyphenyl)prop-2-en-1-ol 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 2309-07-1 Methyl ferulate 
• 100-44-7 benzyl chloride 
• 38157-08-3 (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 93878-20-7 methyl (E)-3-[4-(benzyloxy)-3-methoxyphenyl]acrylate 

Downstream Products

• 301346-50-9 threo-(1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-epoxy-1-propanol 
• 1257993-01-3 threo-(1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-3-O-tosyl-1,2,3-propanetriol 
• 1257993-03-5 threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol 
• 171485-39-5 (-)?erythro?(7S,8R)?Δ^8′?4,7?dihydroxy?3,3',5'-tetramethoxy?8?O?4′?neolignan 
• 301346-51-0 (1S,2R)-4-benzyloxy-3-[2,3-epoxy-1-(4-benzyloxy-3-methoxyphenyl)propoxy]benzaldehyde 
• 301346-52-1 (1S,2R)-4-hydroxy-3-[2,3-epoxy-1-(4-hydroxy-3-methoxyphenyl)propoxy]benzaldehyde 
• 300678-40-4 (2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde 

Relevant articles and documents

Asymmetric synthesis of the natural erythro-(1R,2S)-8-O-4′-neolignan myrislignan

An efficient and practical asymmetric synthesis of erythro-(1R,2S)-8-O- 4′-neolignan myrislignan was achieved by using vanillin and pyrogallic acid as the starting materials. Two key steps are involved: preparation of an enantiopure threo alcohol of predictable stereochemistry by dihydroxylation with AD-mix-β, and inversion of the absolute configuration from the threo to the erythro isomer using a Mitsunobu reaction. The route illustrates a new methodology for the synthesis of erythro-8-O-4′-neolignan. Graphical abstract: [Figure not available: see fulltext.]

First enantioselective syntheses of (2R,3R)- and (2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde

An enantioselective and regioselective total synthesis approach to chiral 1,4-benzodioxane lignans (2R,3R)- and (2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde is reported. Copyright (C) 2000 Elsevier Science Ltd.