1257993-03-5

Basic information

• Product Name: threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol
• CAS NO: 1257993-03-5
• Molecular Weight: 326.39
• Mol File: 1257993-03-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol(1257993-03-5)
• EPA Substance Registry System: threo-(1R,2R)-1-[3-methoxy-4-(methoxymethoxy)phenyl]-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol(1257993-03-5)

Safety Data

• Hazardous Substances Data: 1257993-03-5(Hazardous Substances Data)

Upstream product

• 300678-35-7 (1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-2,3-dihydroxypropanol 
• 121-33-5 vanillin 
• 38157-08-3 (E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester 
• 38153-27-4 (2E)-3-(4-O-benzyloxy-3-methoxyphenyl)prop-2-en-1-ol 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 107-30-2 chloromethyl methyl ether 
• 1257993-02-4 threo-(1R,2R)-1-(4-benzyloxy-3-methoxyphenyl)-1-(2,3,4,5-tetrahydropyran-2-yloxy)-2-propanol 

Downstream Products

• 171485-39-5 (-)?erythro?(7S,8R)?Δ^8′?4,7?dihydroxy?3,3',5'-tetramethoxy?8?O?4′?neolignan 

Relevant articles and documents

Asymmetric synthesis of the natural erythro-(1R,2S)-8-O-4′-neolignan myrislignan

An efficient and practical asymmetric synthesis of erythro-(1R,2S)-8-O- 4′-neolignan myrislignan was achieved by using vanillin and pyrogallic acid as the starting materials. Two key steps are involved: preparation of an enantiopure threo alcohol of predictable stereochemistry by dihydroxylation with AD-mix-β, and inversion of the absolute configuration from the threo to the erythro isomer using a Mitsunobu reaction. The route illustrates a new methodology for the synthesis of erythro-8-O-4′-neolignan. Graphical abstract: [Figure not available: see fulltext.]