30082-52-1Relevant articles and documents
Multicomponent synthesis of pyrroles from cyclopropanes: A one-pot palladium(0)-catalyzed dehydrocarbonylation/dehydration
Humenny, William J.,Kyriacou, Polydoros,Sapeta, Katarina,Karadeolian, Avedis,Kerr, Michael A.
supporting information, p. 11088 - 11091 (2013/01/15)
Ring the changes: The cycloaddition of nitrones with 1-carboallyloxy-1- carbomethoxycyclopropanes yields tetrahydro-1,2-oxazines, which in turn undergo a Tsuji dehydrocarbonylation to give dihydro-1,2-oxazines (see scheme; dba=dibenzylideneacetone). Addition of base to this reaction mixture results in clean conversion to pyrroles. The result is a flexible three-component strategy for the synthesis of tetrasubstituted pyrroles. Copyright