301296-47-9

Basic information

• Product Name: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile
• Synonyms: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile
• CAS NO: 301296-47-9
• Molecular Weight: 456.544
• Mol File: 301296-47-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile(301296-47-9)
• EPA Substance Registry System: 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile(301296-47-9)

Safety Data

• Hazardous Substances Data: 301296-47-9(Hazardous Substances Data)

Upstream product

• 71556-74-6 3-Ethyl-hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one 
• 275807-76-6 2-fluoro-4-[amino-(1-methyl-1H-imidazol-5-yl)methyl]benzonitrile 
• 222978-24-7 acetic acid (4-cyano-3-fluorophenyl)(1-trityl-1H-imidazol-4-yl)methyl ester 
• 222978-23-6 2-Fluoro-4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-benzonitrile 
• 222978-25-8 acetic acid (4-cyano-3-fluorophenyl)(3-methyl-3H-imidazol-4-yl)methyl ester 
• 222978-26-9 2-Fluoro-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile 
• 101048-76-4 4-cyano-3-fluorobenzaldehyde 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 222978-02-1 2-fluoro-4-(hydroxymethyl)benzonitrile 
• 222978-01-0 4-bromo-3-fluorobenzyl alcohol 
• 71556-72-4 3-Ethyl-hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one 
• 71592-43-3 hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one 
• 452-74-4 4-bromo-3-fluorotoluene 
• 766-51-8 2-Chloroanisole 

Downstream Products

• 301296-23-1 2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-[1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzonitrile 

Relevant articles and documents

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

A series of novel diaryl ether lactams have been identified as very potent dual inhibitors of protein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I), enzymes involved in the prenylation of Ras. The structure of the complex formed between one of these compounds and FTase has been determined by X-ray crystallography. These compounds are the first reported to inhibit the prenylation of the important oncogene Ki-Ras4B in vivo. Unfortunately, doses sufficient to achieve this endpoint were rapidly lethal.