303111-43-5 Usage
General Description
(R)-1-Benzyl-Beta-Prolinol is a chemical compound with the formula C13H17NO. It is a chiral amino alcohol that is used as a chiral ligand in asymmetric hydrogenation and asymmetric transfer hydrogenation reactions. (R)-1-BENZYL-BETA-PROLINOL has been studied for its potential application in the synthesis of pharmaceutical intermediates and natural products. It has also been reported to be effective in the catalytic enantioselective addition of diethylzinc to aldehydes. Additionally, (R)-1-Benzyl-Beta-Prolinol has been investigated for its potential antiviral and anticancer properties, and has shown promise in inhibiting the growth of certain cancer cell lines.
Check Digit Verification of cas no
The CAS Registry Mumber 303111-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,3,1,1 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 303111-43:
(8*3)+(7*0)+(6*3)+(5*1)+(4*1)+(3*1)+(2*4)+(1*3)=65
65 % 10 = 5
So 303111-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2/t12-/m1/s1
303111-43-5Relevant articles and documents
A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl β-proline
Felluga, Fulvia,Pitacco, Giuliana,Prodan, Massimo,Pricl, Sabrina,Visintin, Marco,Valentin, Ennio
, p. 3241 - 3249 (2007/10/03)
Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and α-chymotrypsin, for which the enantiomeric ratio, E, exceeded 200. The absolute configurations of the lactams were determined by means of CD spectroscopy. From the resulting enantiomerically pure (99% e.e.) (S)-(+)-1-benzyl-3-pyrrolidinecarboxylic acid and methyl (R)-(-)-1-benzyl-3-pyrrolidinecarboxylate, the methyl esters of (+) and (-)-β-proline were synthesised in 99% e.e. and 18 and 22% overall yield, respectively.
