428518-36-9 Usage
General Description
(R)-1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is a chemical compound with a molecular formula of C14H15NO3. It is a derivative of pyrrolidine and functions as a methyl ester. (R)-1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER contains a benzyl group, a carboxylic acid group, and a methyl ester group, making it useful in organic synthesis and drug development. It has potential applications in pharmaceuticals, as well as in the production of other organic compounds. This chemical's structure and properties make it of interest to researchers for its potential uses in various fields of chemistry and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 428518-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,8,5,1 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 428518-36:
(8*4)+(7*2)+(6*8)+(5*5)+(4*1)+(3*8)+(2*3)+(1*6)=159
159 % 10 = 9
So 428518-36-9 is a valid CAS Registry Number.
428518-36-9Relevant articles and documents
A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl β-proline
Felluga, Fulvia,Pitacco, Giuliana,Prodan, Massimo,Pricl, Sabrina,Visintin, Marco,Valentin, Ennio
, p. 3241 - 3249 (2007/10/03)
Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and α-chymotrypsin, for which the enantiomeric ratio, E, exceeded 200. The absolute configurations of the lactams were determined by means of CD spectroscopy. From the resulting enantiomerically pure (99% e.e.) (S)-(+)-1-benzyl-3-pyrrolidinecarboxylic acid and methyl (R)-(-)-1-benzyl-3-pyrrolidinecarboxylate, the methyl esters of (+) and (-)-β-proline were synthesised in 99% e.e. and 18 and 22% overall yield, respectively.
