303149-14-6 Usage
Description
HT-2157 is a galanin-3 receptor antagonist that has been developed for the treatment of alcohol use disorder and opioid addiction.
Uses
Used in Pharmaceutical Industry:
HT-2157 is used as a therapeutic agent for the treatment of alcohol use disorder and opioid addiction. It works by selectively targeting the galanin-3 receptor, which has been implicated in the regulation of alcohol and opioid consumption. By blocking this receptor, HT-2157 can reduce the rewarding effects of alcohol and opioids, thereby decreasing the desire to consume these substances and promoting abstinence.
Used in Research:
HT-2157 is also used as a research tool for studying the role of the galanin-3 receptor in various physiological and pathological processes. It can help researchers gain a better understanding of the mechanisms underlying alcohol and opioid addiction, as well as other related disorders. This knowledge can then be used to develop new and more effective treatments for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 303149-14-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,3,1,4 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 303149-14:
(8*3)+(7*0)+(6*3)+(5*1)+(4*4)+(3*9)+(2*1)+(1*4)=96
96 % 10 = 6
So 303149-14-6 is a valid CAS Registry Number.
303149-14-6Relevant articles and documents
3-Arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists
Konkel, Michael J.,Lagu, Bharat,Boteju, Lakmal W.,Jimenez, Hermogenes,Noble, Stewart,Walker, Mary W.,Chandrasena, Gamini,Blackburn, Thomas P.,Nikam, Sham S.,Wright, Jon L.,Kornberg, Brian E.,Gregory, Tracy,Pugsley, Thomas A.,Akunne, Hyacinth,Zoski, Kim,Wise, Lawrence D.
, p. 3757 - 3758 (2006)
A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (9), was shown to have high affinity for the
