303162-49-4

Basic information

• Product Name: Ethanone, 2-(2-fluoro-4-pyridinyl)-1-(3-methylphenyl)-
• CAS NO: 303162-49-4
• Molecular Formula: C14H12FNO
• Molecular Weight: 229.254
• Mol File: 303162-49-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(2-fluoro-4-pyridinyl)-1-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(2-fluoro-4-pyridinyl)-1-(3-methylphenyl)-(303162-49-4)
• EPA Substance Registry System: Ethanone, 2-(2-fluoro-4-pyridinyl)-1-(3-methylphenyl)-(303162-49-4)

Safety Data

• Hazardous Substances Data: 303162-49-4(Hazardous Substances Data)

Upstream product

• 461-87-0 2-fluoro-4-methylpyridine 
• 21384-43-0 1-(3-methylbenzoyl)-2-methylaziridine 

Downstream Products

• 303162-55-2 5-(2-fluoro-pyridin-4-yl)-4-(3-methylphenyl)-2-(4-methylthiophenyl)-1,3-thiazole 
• 303162-52-9 [5-(2-fluoro-pyridin-4-yl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]amine 
• 365428-57-5 2-ethyl-5-(2-fluoro-pyridin-4-yl)-4-(3-methylphenyl)-1,3-thiazole 
• 791053-96-8 2-bromo-2-(2-fluoro-4-pyridyl)-1-(3-methylphenyl)ethanone hydrobromide 

Relevant articles and documents

Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent

The p38 mitogen-activated protein (MAP) kinase has been implicated in the proinflammatory cytokine signal pathway, and its inhibitors are potentially useful for the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA) and inflammat

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.