303957-69-9 Usage
General Description
Reutericyclin is a cyclic peptide antibiotic produced by certain strains of Lactobacillus reuteri bacteria. It is known for its strong anti-microbial activity against various pathogenic bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Clostridium difficile. Reutericyclin has been shown to be effective in inhibiting the growth of these bacteria by disrupting their cell membranes and inhibiting their protein synthesis. It also has potential applications in food preservation and as a therapeutic agent in the treatment of bacterial infections. Reutericyclin is a promising natural compound that could have a significant impact in the field of antibiotic research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 303957-69-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,3,9,5 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 303957-69:
(8*3)+(7*0)+(6*3)+(5*9)+(4*5)+(3*7)+(2*6)+(1*9)=149
149 % 10 = 9
So 303957-69-9 is a valid CAS Registry Number.
303957-69-9Relevant articles and documents
Synthesis of the antibiotic (R)-reutericyclin via Dieckmann condensation
Boehme, Roswitha,Jung, Guenther,Breitmaier, Eberhard
, p. 2837 - 2841 (2005)
(R)-Reutericyclin ((R)-1), a bactericidal, amphiphilic natural product with a trisubstituted tetramic acid moiety, was prepared in four steps from D-leucine in anoverall yieldof 24%. The chiral heterocyclic portion of 1 was synthesized by Dieckmann cyclization of ethyl N-(acetoacetyl)leucinate (7), and the resulting pyrrole derivative 8 was N-acylated with (E)-dec-2-enoyl chloride in the presence of BuLi at-70° (Scheme2). This new procedure is straightforward and allows the synthesis of both antipodes of reutericyclin in anenantiomeric excess (ee) of ca. 80%.
