3049-45-4Relevant articles and documents
Selective Zn2+ recognition of novel triazole Schiff-base derivatives bearing the coumarin group
Wang, Wei,Qi, Shuai,Liu, Qing-Lei,Lei, Ya-Nan,Yuan, Wen-Jing,Gao, Yan
, p. 604 - 606 (2014)
Three novel triazole Schiff-bases derivatives bearing coumarin units have been synthesised from 3,5-diaryl-4-amino-1,2,4-triazole with three kinds of coumarin aldehydes. The UV.Vis absorption and fluorescence emission spectra of (E )-4-((3,5-diphenyl-4H-
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
Raghav, Neera,Singh, Mamta
, p. 231 - 242 (2014)
In the past decade, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases has been in focus. In this direction, we here present the facile microwave assisted synthesis of some acyl hydrazides and triazoles, followed by their evaluation as protease inhibitors and inhibitory studies on cathepsin B and cathepsin H, two significant lysosomal cysteine proteases. The compounds were characterized by 1H NMR, 13C NMR, Mass and IR spectral data. The compounds which were found inhibitory to endogenous proteolysis in liver homogenate at pH 5.0 were further studied for determination of inhibition type and Ki values on purified cathepsin B and cathepsin H. The maximum inhibitory effect was exerted by 3-(3′-nitrophenyl)-5-(3′-nitrophenyl)-4-amino-1,2,4-triazoles (2c), 3-(4′-chlorophenyl)-5-(4′-chloro phenyl)-4-amino-1,2,4- triazoles (2h), 3-(3′-aminophenyl)-5-(3′-aminophenyl)-4-amino-1,2,4- triazoles (2i) and 4-methoxybenzohydrazide (1b).
Synthesis, extraction and antibacterial studies of some new bis-1,2,4-triazole derivatives part II
Guemruekcueoglu, Nurhan,Ugras, Serpil,Ugras, Halil Ibrahim,Cakir, Uemit
experimental part, p. 359 - 367 (2012/10/07)
The treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole 3 with various bis-aldehydes resulted in the formation of bis-4-arylidenamino-3,5-diphenyl-4H- 1,2,4-triazoles (4a-d) derivatives. NaBH4 reduction of 4-arylidenamino derivatives of 1,2,4-t