14478-73-0

Basic information

• Product Name: 3,6-Diphenyl-1,4-dihydro-1,2,4,5-tetrazine
• Synonyms: 1,4-Dihydro-3,6-diphenyl-1,2,4,5-tetrazine;3,6-Diphenyl-1,4-dihydro-1,2,4,5-tetrazine
• CAS NO: 14478-73-0
• Molecular Formula: C₁₄H₁₂N₄
• Molecular Weight: 236.2719
• Mol File: 14478-73-0.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 365.6°Cat760mmHg
• Flash Point: 174.9°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 1.55E-05mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 3,6-Diphenyl-1,4-dihydro-1,2,4,5-tetrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Diphenyl-1,4-dihydro-1,2,4,5-tetrazine(14478-73-0)
• EPA Substance Registry System: 3,6-Diphenyl-1,4-dihydro-1,2,4,5-tetrazine(14478-73-0)

Safety Data

• Hazardous Substances Data: 14478-73-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 1463, 1962 DOI: 10.1021/jo01051a521Tetrahedron Letters, 16, p. 4527, 1975

InChI:InChI=1/C14H12N4/c1-3-7-11(8-4-1)13-15-17-14(18-16-13)12-9-5-2-6-10-12/h1-10H,(H,15,16)(H,17,18)

Upstream product

• 729-44-2 1,2-bis[chloro(phenyl)methylidene]hydrazone 
• 109516-31-6 N,N'-methanediyl-bis-thiobenzamide 
• 100-47-0 benzonitrile 
• 2227-79-4 benzenecarbothioamide 
• 825-60-5 benzimidic acid ethyl ester 
• 20605-40-7 thiobenzoylhydrazine 
• 74-88-4 methyl iodide 
• 302-01-2 hydrazine 
• 7803-57-8 hydrazine hydrate 
• 31646-28-3 4-((methylthio)(phenyl)methylene) morpholinium iodide 
• 6830-78-0 3,6-diphenyl-1,2,4,5-tetrazine 
• 98-07-7 Benzotrichlorid 
• 1575-94-6 N,N'-methylenebisbenzamide 
• 787-84-8 N'-benzoylbenzohydrazide 

Downstream Products

• 6830-78-0 3,6-diphenyl-1,2,4,5-tetrazine 
• 2039-06-7 3,5-diphenyl-1,2,4-triazole 
• 3049-45-4 4-amino-3,5-diphenyl-4H-1,2,4-triazole 
• 18674-01-6 2-(3,5-diphenyl-[1,2,4]triazol-1-yl)-1,1,1,3,3,3-hexamethyl-disilazane 
• 58822-95-0 1,2-Dimethyl-3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazin 
• 52143-15-4 1,4-dimethyl-3,6-diphenyl-1,4-dihydro-1,2,4,5-tetrazine 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 14850-88-5 benzoylhydrazone of benzaldehyde 
• 34985-93-8 1-amino-3,5-diphenyl-1,2,4-triazole 

Relevant articles and documents

Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives

Fourteen compounds of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives were prepared and their structures were confirmed by single-crystal X-ray diffraction and the semi-empirical calculation of PM3 method. This reaction yields the 1,4-dihydro derivatives rather than the 1,2-dihydro derivatives. The central six-membered ring of 1,4-dihydro-1,2,4,5-tetrazine has a chair conformation and therefore is not homoaromatic. Their antitumor activities were evaluated in vitro by SRB method for A-549 and BEL-7402 cells, and MTT method for P-388 and HL-60 cells. The results show that there is one compound which is highly effective against P-388 cells and one compound which is highly effective against HL-60 cells. So it is a kind of compound which possesses potential antitumor activities and is worth to research further.

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Microporous material based on π-π Stacking of 1,4-bis(3,6- diphenylpyridazin-4-yl)benzene

A microporous material constructed by π-π interaction of a twisted H-shape poly-aromatic molecule, 1,4-bis(3,6-diphenylpyridazin-4-yl)benzene (1) was synthesized and X-ray quality crystals were isolated. The intermolecular distances between the various ar

Scandium ion-promoted reduction of heterocyclic N = N double bond. Hydride transfer vs electron transfer

Hydride transfer from 10-methyl-9,10-dihydroacridine (AcrH2) to 3,6-diphenyl-1,2,4,5-tetrazine (Ph2Tz), which contains a N=N double bond, occurs efficiently in the presence of Sc(OTf)3 (OTf = OSO2-CF3

3,6-Substituted-1,2,4,5-tetrazines: Tuning reaction rates for staged labeling applications

Cycloaddition reactions involving tetrazines have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate. By varying th