305375-94-4

Basic information

• Product Name: 3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
• Synonyms: 3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine
• CAS NO: 305375-94-4
• Molecular Weight: 213.214
• Mol File: 305375-94-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(305375-94-4)
• EPA Substance Registry System: 3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine(305375-94-4)

Safety Data

• Hazardous Substances Data: 305375-94-4(Hazardous Substances Data)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 405-99-2 para-fluorostyrene 
• 110-86-1 pyridine 
• 459-57-4 4-fluorobenzaldehyde 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 456-22-4 4-Fluorobenzoic acid 
• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 352-34-1 4-fluoro-1-iodobenzene 
• 176662-02-5 2-(2-(4-fluorobenzylidene)hydrazinyl)pyridine 

Relevant articles and documents

An environmentally benign and solvent-free synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-5-methyl[1,2,4]triazolo[4,3-a] quinolines using phenyliodine bis(trifluoroacetate) or iodobenzene diacetate

A simple, solvent-free and effective method for oxidative cyclization of 2-pyridyl- and 2-quinolylhydrazones with phenyliodine bis(trifluoroacetate) and iodobenzene diacetate to the corresponding 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl[1,2,4]tria

Method for preparing 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis

The invention discloses a method for preparing a 3-phenyl-[1,2,4] triazole [4,3-a] pyridine compound without metal catalysis. The method comprises the following steps: enabling a pyridine compound, sodium azide and a benzaldehyde compound to react suffici

[1,2,4]-triazol [4,3-a] pyridines compound and synthesis method thereof

The invention discloses a [1,2,4]-triazol [4,3-a] pyridines compound and a synthesis method thereof. The compound has a structure general formula shown as the formula (I), wherein R1 is selected fromaryl and heterocyclic groups; R2 is selected from hydrogen, alkyl, alkoxy, halogen or aryl. According to the synthesis method, alpha-ketonic acid and 2-hydrazinopyridine are used as raw materials; KIis used as a catalyst; Na2CO3 is used as alkali; TBHP is used as an oxidizing agent; 1,4-dioxane is used as a solvent; after a series of serial connection cyclization and decarboxylation aromatization, the [1,2,4]-triazol [4,3-a] pyridines compound is obtained. The [1,2,4]-triazol [4,3-a] pyridines compound is prepared under the condition of no transition metal and has the advantages that the reaction is efficient and fast; the conditions are mild; the substrate is simple and can be easily obtained; the applicability is wide; the reaction time is short; the yield is high, and the like; meanwhile, the post treatment of the reaction is simple and convenient; the harm to experiment operators is reduced; the environment-friendly effect is achieved; the green chemical requirements are met.