305819-40-3Relevant articles and documents
A photochemical approach to phenylalanines and related compounds by alkylation of glycine
Knowles, Haydn S.,Hunt, Keith,Parsons, Andrew F.
, p. 8115 - 8124 (2007/10/03)
Phenylalanines can be prepared on UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, substituted toluenes and the photosensitiser benzophenone. These reactions, which lead to highly selective mono-alkylation at the α-position of glycines, involve coupling of captodative α-glycine radicals with benzyl radicals. This method can be used to selectively alkylate a variety of glycine derivatives using a range of substituted toluenes under neutral reaction conditions.