30751-05-4

Basic information

• Product Name: Troxipide
• Synonyms: Aplace;Benzamide, 3,4,5-trimethoxy-N-3-piperidinyl- (9CI);Benzamide, 3,4,5-trimethoxy-N-3-piperidyl- (8CI);KU 54;N-(3-Piperidyl)-3,4,5-trimethoxybenzamide;Benzamide, 3,4,5-trimethoxy-N-3-piperidinyl-;3,4,5-trimethoxy-n-(3-piperidyl)benzamide;TROXIPIDE
• CAS NO: 30751-05-4
• Molecular Formula: C₁₅H₂₂N₂O₄
• Molecular Weight: 294.35
• EINECS: 1312995-182-4
• Product Categories: Inhibitors
• Mol File: 30751-05-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 177.0 to 181.0 °C
• Boiling Point: 407.5 °C at 760 mmHg
• Flash Point: 200.3 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 7.51E-07mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.66±0.20(Predicted)
• CAS DataBase Reference: Troxipide(CAS DataBase Reference)
• NIST Chemistry Reference: Troxipide(30751-05-4)
• EPA Substance Registry System: Troxipide(30751-05-4)

Safety Data

• RTECS: CV5792600
• Hazardous Substances Data: 30751-05-4(Hazardous Substances Data)

Usage

Description

Troxipide, branded as APLACE, is an antiulcer agent that is believed to exert its therapeutic effects through the enhancement of gastric glycoprotein metabolism and improvement of blood flow in the gastric mucosa. It is a pharmaceutical compound specifically designed to address gastrointestinal issues, particularly gastroesophageal reflux disease (GERD).

Uses

Used in Pharmaceutical Industry:
Troxipide is used as a therapeutic agent for the treatment of gastroesophageal reflux disease (GERD) due to its ability to inhibit chemotactic migration and superoxide generation in the gastric mucosa. This action helps in reducing inflammation and promoting healing of the affected tissues in the gastrointestinal tract.
Additionally, Troxipide is used as an antiulcer agent to improve gastric glycoprotein metabolism and blood flow, which contributes to the overall health and integrity of the stomach lining. This dual action makes Troxipide a valuable asset in the management and treatment of various gastrointestinal disorders.

Originator

Kyorin (Japan)

InChI:InChI=1/C15H22N2O4/c1-19-12-7-10(8-13(20-2)14(12)21-3)15(18)17-11-5-4-6-16-9-11/h7-8,11,16H,4-6,9H2,1-3H3,(H,17,18)

Upstream product

• 118-41-2 Eudesmic acid 
• 31638-96-7 3,4,5-trimethoxy-N-3-pyridylbenzamide 

Relevant articles and documents

Troxipide preparation method

The invention belongs to the field of pharmaceutical chemical synthesis and relates to a troxipide preparation method. The preparation method includes steps: 1) preparing 3,4,5-triethoxy benzoyl chloride from 3,4,5-trimethoxybenzoic acid and triphosgene in an organic solvent under the catalytic action of an amine catalyst, subjecting to condensation reaction with 3-aminopyridine in an organic solvent in existence of inorganic base, and performing aftertreatment to obtain 3,4,5-triethoxy-N-3-pyridylbenzamide; 2) subjecting the 3,4,5-triethoxy-N-3-pyridylbenzamide to catalytic hydrogenation to obtain a crude product of troxipide, and refining to obtain troxipide. The troxipide preparation method has advantages of easiness in raw material acquisition, short reaction steps, mild conditions, simplicity in aftertreatment, high product quality, high purity and suitableness for industrial production.