30780-51-9

Basic information

• Product Name: 4-Pentynoic acid, 5-phenyl-, methyl ester
• CAS NO: 30780-51-9
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol File: 30780-51-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-Pentynoic acid, 5-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentynoic acid, 5-phenyl-, methyl ester(30780-51-9)
• EPA Substance Registry System: 4-Pentynoic acid, 5-phenyl-, methyl ester(30780-51-9)

Safety Data

• Hazardous Substances Data: 30780-51-9(Hazardous Substances Data)

Upstream product

• 6089-09-4 4-pentynoic acid 
• 52843-77-3 phenylethynyl trifluoromethyl sulfone 
• 3350-92-3 5-phenylpent-4-ynoic acid 
• 74-88-4 methyl iodide 
• 4312-99-6 oct-1-en-3-one 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 78-94-4 methyl vinyl ketone 
• 292638-85-8 acrylic acid methyl ester 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 591-50-4 iodobenzene 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 30625-91-3 (E)-5-phenylpent-2-en-4-ynal 

Downstream Products

• 33599-84-7 methyl (E)-5-phenyl-4-pentenoate 
• 38447-05-1 (2E,4E)-methyl 5-phenylpenta-2,4-dienoate 
• 1435517-90-0 3-(4-chlorophenyl)-2,4a-dihydro-1H-fluoren-4-yl benzoate 
• 1435517-82-0 6-bromo-3-phenyl-2,4a-dihydro-1H-fluoren-4-yl benzoate 
• 1435518-59-4 3-cyclopropyl-7-phenylhepta-1,6-diyn-3-yl benzoate 
• 1435518-58-3 3-(naphthalen-1-yl)-7-phenylhepta-1,6-diyn-3-yl benzoate 
• 1435518-57-2 7-phenyl-3-(4-vinylphenyl)hepta-1,6-diyn-3-yl benzoate 
• 1435518-56-1 3-(4-chlorophenyl)-7-phenylhepta-1,6-diyn-3-yl benzoate 
• 1435518-41-4 tert-butyl (3,7-diphenylhepta-1,6-diyn-3-yl)carbonate 
• 1435518-40-3 benzyl (3,7-diphenylhepta-1,6-diyn-3-yl)carbonate 
• 1435518-39-0 3,7-diphenylhepta-1,6-diyn-3-yl acetate 
• 1435518-38-9 3,7-diphenylhepta-1,6-diyn-3-yl benzoate 
• 1435518-37-8 3,7-diphenylhepta-1,6-diyn-3-yl 4-nitrobenzoate 
• 1435518-34-5 3-cyclopropyl-7-phenyl-1-(trimethylsilyl)hepta-1,6-diyn-3-ol 

Relevant articles and documents

A NEW PRACTICAL METHOD FOR THE SYNTHESIS OF ACETYLENES

The reaction of isoxazol-5-ones derived from β-keto esters and hydroxylamine with sodium nitrite and ferrous sulphate in aqueous acetic acid affords the corresponding acetylenes in moderate to good yield. Key Words: Alkynes; Isoxazol-5-ones; β-Keto esters

Diversity-Oriented Desulfonylative Functionalization of Alkyl Allyl Sulfones

The diversity-oriented desulfonylative functionalization of alkyl allyl sulfones with various sulfone-type reagents by radical chemistry has been developed. The readily installed allylsulfonyl moiety acts as a C-radical precursor, which is substituted by various functionalities using sulfur-based radical trapping reagents. The generality of this approach is documented by the successful desulfonylative alkynylation, azidation, trifluoromethylthiolation, sulfenylation, trifluoromethylselenylation, halogenation, and deuteration. The method is compatible with a wide range of functional groups. Considering the deuteration, products are obtained in good yields with a high level of deuterium incorporation.

Asymmetric Three-Component Coupling Reaction of Alkyne, Enone, and Aldehyde Catalyzed by Chiral Phebox Ruthenium Catalysts

Catalytic asymmetric three-component coupling reactions of terminal alkynes, α,β-unsaturated ketones, and aldehydes were studied. The chiral ruthenium complexes containing bis(oxazolinyl)phenyl ligands were found to serve as efficient catalysts for a tandem reaction based on conjugate addition of terminal alkynes to α,β-unsaturated ketones and subsequent aldol reaction with aldehydes, giving β-hydroxyketone derivatives containing α-propargyl groups in high yields with moderate to good enantioselectivities. This method can produce various functional molecules from commercially available substrates in a one-pot procedure. The absolute configuration of the major product was determined by X-ray analysis. The control experiments suggested that a ruthenium enolate species generated in situ by conjugate addition could be involved as an intermediate for the aldol coupling with an aldehyde.