3081-28-5

Basic information

• Product Name: D-phenylalanine tert-butyl ester
• CAS NO: 3081-28-5
• Molecular Weight: 221.299
• Mol File: 3081-28-5.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: D-phenylalanine tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-phenylalanine tert-butyl ester(3081-28-5)
• EPA Substance Registry System: D-phenylalanine tert-butyl ester(3081-28-5)

Safety Data

• Hazardous Substances Data: 3081-28-5(Hazardous Substances Data)

Upstream product

• 188591-76-6 tert-butyl (2,2,2-trifluoroacetyl)-L-phenylalaninate 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 100-39-0 benzyl bromide 
• 83080-24-4 tert-butyl phenylpyruvate 
• 226900-30-7 tert-butyl 2-((diphenylmethylene)amino)-3-phenylpropanoate 
• 673-06-3 D-(R)-phenylalanine 
• 104505-09-1 [1,7,7-Trimethyl-bicyclo[2.2.1]hept-(2E)-ylideneamino]-acetic acid tert-butyl ester 
• 6456-74-2 Glycine tert-butyl ester 
• 2448-45-5 Cbz-D-Phe 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 
• 115-11-7 isobutene 
• 540-88-5 acetic acid tert-butyl ester 
• 113723-87-8 tert-butyl (R)-3'-phenyl-2'-([1R,2E,4R]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylideneamino)propanoate 
• 112924-08-0 tert-butyl N-(benzyloxycarbonyl)-D-phenylalaninate 

Downstream Products

• 203640-15-7 (R)-2-(4-Iodo-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester 
• 172793-43-0 di-tert-butyl L-γ-glutamyl-D-phenylalaninate 
• 145789-01-1 (S)-4-((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester 
• 1215220-08-8 C₂₉H₂₇N₃O₃ 
• 1256640-08-0 C₂HF₃O₂*C₁₃H₁₉NO₂ 
• 868845-09-4 N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys] 
• 1300683-56-0 Fmoc-Gly-Asp(OBn)-D-Phe-Ot-Bu 
• 1300683-57-1 Fmoc-Arg(Ts)-Gly-Asp(OBn)-D-Phe-Ot-Bu 
• 1300683-58-2 Boc-Lys(Z)-Arg(Ts)-Gly-Asp(OBn)-D-Phe-Ot-Bu 
• 1300683-60-6 Lys(Z)-Arg(Ts)-Gly-Asp(OBn)-D-Phe-OH*TFA 
• 250612-43-2 cyclo[Arg(Ts)-Gly-Asp(OBn)-D-Phe-Lys(Z)] 
• 1300683-67-3 Fmoc-Arg(NO₂)-Gly-Asp(OBn)-D-Phe-Ot-Bu 
• 1300683-70-8 Boc-Lys(Z)-Arg(NO₂)-Gly-Asp(OBn)-D-Phe-Ot-Bu 
• 1300683-72-0 Lys(Z)-Arg(NO₂)-Gly-Asp(OBn)-D-Phe-OH*TFA 

Relevant articles and documents

Recoverable Dendritic Phase-Transfer Catalysts that Contain (+)-Cinchonine-Derived Ammonium Salts

Four new phosphorus dendrimeric phase-transfer catalysts are prepared that contain 12 (+)-cinchoninium salts on the surface obtained by the quaternisation of the quinuclidinic N atom. The asymmetric alkylation of a glycinate Schiff base with benzyl bromide is used as a benchmark reaction, and the dendrimeric catalyst that contains an allyl group on the O-9 hydroxy group of the cinchonine units is the most active. The recovery and reuse of the catalyst are possible for five consecutive runs without loss of activity and with only a slight decrease in enantioselectivity. If other electrophiles are used, substituted benzyl bromides give better results than other activated alkyl bromides to afford the corresponding R amino acid derivatives. A comparison of these results with those reported previously for similar cinchoninium salts shows that dendrimers could be a better support than other polymers for this type of organocatalysis.

MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF

The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula (I) compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.

A practical large-scale synthesis of cyclic RGD pentapeptides suitable for further functionalization through click' chemistry

A multigram batch of the cyclo[Arg-Gly-Asp-d-Phe-Lys] and its N - azido derivative was accomplished via solution-phase synthesis using an epimerization-free fragment condensation. The C-terminus of d-Phe was protected as its tert-butyl ester. Fmoc (Arg, Gly, Asp, d-Phe) and Boc (Lys) groups were used to protect all N - termini. The Ts and NO2 groups, respectively were chosen to protect the guanidine group. The macrocyclization step (between d-Phe and l-Lys) was carried out under TBTU/HOBt or DPPA condensation conditions. Finally, the -amino group of the lysine residue was selectively converted into the azido group by a diazo-transfer reaction. Georg Thieme Verlag Stuttgart New York.