308348-93-8

Basic information

• Product Name: METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE
• Synonyms: METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE;5-Pyrimidinecarboxylicacid,2-amino-,methylester(9CI);5-PyriMidinecarboxylic acid, 2-aMino-, Methyl ester;EOS-60345
• CAS NO: 308348-93-8
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Product Categories: CARBOXYLICESTER;Heterocycle-Pyrimidine series
• Mol File: 308348-93-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 344.232 °C at 760 mmHg
• Flash Point: 161.986 °C
• Appearance: /
• Density: 1.319
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE(308348-93-8)
• EPA Substance Registry System: METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE(308348-93-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 308348-93-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-aminopyrimidine-5-carboxylate is a chemical compound with the molecular formula C7H9N3O2. It is a derivative of pyrimidine and contains a methyl group, an amino group, and a carboxylate group. METHYL 2-AMINOPYRIMIDINE-5-CARBOXYLATE is commonly used as an intermediate in organic synthesis for the production of pharmaceuticals, agrochemicals, and other fine chemicals. It may also be utilized as a building block for the preparation of various heterocyclic compounds. Methyl 2-aminopyrimidine-5-carboxylate is a white to off-white crystalline solid with a molecular weight of 163.16 g/mol. It is important to handle and store this compound according to established safety procedures and guidelines to avoid any potential hazards.

Upstream product

• 50-01-1 guanidine hydrochloride 
• 67-56-1 methanol 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 201230-82-2 carbon monoxide 
• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 107-31-3 Methyl formate 
• 506-93-4 guanidine nitrate 
• 80-62-6 methacrylic acid methyl ester 

Downstream Products

• 1001341-83-8 methyl 2-((4-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carboxylate 
• 1001341-91-8 methyl 2-((3-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carboxylate 
• 3167-50-8 2-amino-pyrimidine-5-carboxylic acid 
• 120747-84-4 2-aminopyrimidine-5-carboxyaldehyde 
• 944896-64-4 imidazo [1,2-a]pyrimidine-6-carboxylic acid 
• 1083196-24-0 methyl imidazo[1,2-a]pyrimidin-6-carboxylate 
• 287714-35-6 2-chloro-pyrimidine-5-carboxylic acid methyl ester 
• 1581701-25-8 2-amino-N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)pyrimidine-5-carboxamide 
• 1339928-25-4 CUDC-907 
• 1032568-63-0 copanlisib 
• 1001341-93-0 2-((3-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carboxylic acid 
• 1001341-90-7 2-((4-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carbonyl chloride 
• 1001341-86-1 2-((4-(2-pyrrolidin-1-ylethoxy)phenyl)amino)pyrimidine-5-carboxylic acid 

Relevant articles and documents

Synthesis method of copanlisib intermediate methyl 2-aminopyrimidine-5-carboxylate

The invention provides a synthetic method of a copanlisib intermediate methyl 2-aminopyrimidine-5-carboxylate, which comprises the following specific reaction steps: reacting sodium methoxide, ethyl formate and methyl 3,3-dimethoxypropionate in a methanol solvent at room temperature for 5 hours, then adding guanidine hydrochloride, conducting reacting at 50-55 DEG C for 2 hours, conducting cooling to room temperature after the reaction is completed, and conducting filtering and drying to obtain methyl 2-aminopyrimidine-5-carboxylate. The invention solves the problems of tedious reaction, high-risk raw material need, much waste liquid and waste water generated in the production process and the like in the existing reaction of the copanlisib intermediate methyl 2-aminopyrimidine-5-carboxylate, and provides a novel synthetic method of the copanlisib intermeidate methyl 2-aminopyrimidine-5-carboxylate, and the preparation method is simple, safe and controllable in reaction process, cheap and easily available in raw materials, high in yield, less in generated three wastes and the like.

COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY

The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

New tetrahydropyrido pyrimidinecarboxylic compound or salt thereof

To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).