31127-39-6

Basic information

• Product Name: (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe
• Synonyms: (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe;2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe
• CAS NO: 31127-39-6
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17266
• Mol File: 31127-39-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 299.8°Cat760mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0.000521mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.33±0.14(Predicted)
• CAS DataBase Reference: (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe(31127-39-6)
• EPA Substance Registry System: (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe(31127-39-6)

Safety Data

• Hazardous Substances Data: 31127-39-6(Hazardous Substances Data)

Usage

General Description

(E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe is a chemical compound that belongs to the class of benzodioxines. It is an aldehyde derivative that contains a methoxy group (OxiMe) attached to the benzene ring. (E)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxiMe is commonly used in organic synthesis and pharmaceutical research due to its interesting structural features and potential biological activities. Its molecular structure includes a six-membered benzodioxine ring fused to a benzene ring, and the presence of the aldehyde and methoxy functional groups make it a versatile building block for the synthesis of complex organic molecules. Research on this compound is ongoing to explore its potential applications in medicinal chemistry and drug development.

InChI:InChI=1/C9H9NO3/c11-10-6-7-1-2-8-9(5-7)13-4-3-12-8/h1-2,5-6,11H,3-4H2/b10-6-

Upstream product

• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 941710-30-1 3,4-dihydro-2H-7-bromochromene 
• 124362-47-6 3,4-Dihydro-2H-benzopyran-7-carbaldehyde 

Downstream Products

• 808740-73-0 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-isoxazole-5-carbaldehyde 
• 1421869-68-2 C₂₇H₃₁ClN₄O₃*ClH 
• 1421869-56-8 C₂₇H₃₂N₄O₃*ClH 
• 1421869-74-0 C₂₇H₃₁ClN₄O₃*ClH 
• 1421869-80-8 C₂₈H₃₄N₄O₄*ClH 
• 1421869-86-4 C₂₇H₃₁FN₄O₃*ClH 
• 1421869-92-2 C₃₄H₃₆F₂N₄O₃*ClH 
• 1421869-98-8 C₂₉H₃₆N₄O₃*ClH 
• 1421870-04-3 C₂₇H₃₁ClN₄O₃*ClH 
• 1421869-62-6 C₂₇H₃₁FN₄O₃*ClH 
• 31127-40-9 (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride 
• 17413-10-4 2,3-dihydro-1,4-benzodioxin-6-ylmethylamine 
• 19102-07-9 2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile 

Relevant articles and documents

Oxygen-containing benzo-cycloaliphatic amine compounds

The invention provides an oxygen-containing benzo-cycloaliphatic substituted amine compounds and application thereof and specifically relates to the oxygen-containing benzo-cycloaliphatic substitutedamine compounds as shown in a formula I which is described in the specification or pharmaceutically acceptable salts thereof and application of the same to preparation of Staphylococcus aureus goldenpigment synthesis inhibitor type antibacterial agents.

Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria

A novel series of coumarin derivatives 6a–o, bearing isoxazole moieties were designed and synthesized. After that, they were evaluated for melanin synthesis in murine B16 cells and inhibitory effect on the growth of CA (Candida albicans), EC (Escherichia coli), SA (Staphylococcus aureus). It was found that eleven compounds (6b–f, 6j–o) showed a better activity on melanin synthesis than positive control (8-MOP). Among them, compounds 6d (242%) and 6f (390%), with nearly 1.6 and 2.6-fold potency compared with 8-MOP (149%) respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo. Seven halogen substituted compounds exhibited moderate antimicrobial activity against CA. It is interesting that 6e–f and 6l–m, which had two halogens on the benzene showed a comparable activity with Amphotericin B against CA. The evaluation of melanin synthesis in B16 cells and inhibitory effect on bacteria of above structurally diverse derivatives had also led to an outline of structure-activity relationship.

Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo

A new series of chalcone derivatives 1–18, bearing isoxazole moieties were designed and synthesized, and biologically evaluated for their activity on mushroom tyrosinase and melanin synthesis in murine B16 cells. The result indicated that most of prepared compounds 1–18 showed potent activating effect on tyrosinase, especially for 1–2, 4, 6–7, 9 and 15. Among them, compounds 2, 4 and 9 demonstrated the best activity with EC50?=?1.3, 2.5 and 3.0?μmol·L?1respectively, much better than the positive control 8-methoxypsoralan (8-MOP, EC50?=?14.8?μmol·L?1); In B16 cells, all the tested compounds exhibited a stronger activity on melanogenesis than 8-MOP (with the value of 115%). It was interesting that derivatives substituted with halogen (1, 2, 4, 5, 7, 9) were generally more potent. Compounds 2 (463%) and 18 (438%) with 3 and 4-fold potency compared with 8-MOP respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo.