31127-40-9

Basic information

• Product Name: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride
• Synonyms: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride;(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride;1,4-Benzodioxan-6-methylamine Hydrochloride
• CAS NO: 31127-40-9
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 227.6476
• Mol File: 31127-40-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(31127-40-9)
• EPA Substance Registry System: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(31127-40-9)

Safety Data

• Hazardous Substances Data: 31127-40-9(Hazardous Substances Data)

Usage

Description

6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride is an organic compound characterized by its unique chemical structure, which features a benzo[b][1,4]dioxine core with an azidomethyl group attached at the 6th position. 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride is typically utilized as a reagent in the synthesis of various organic molecules, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride is used as a synthetic reagent for the preparation of complex organic molecules, such as 4-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-dihydroisoquinolin-3-one. This application is significant because the target molecule has potential therapeutic properties, which can be further explored for the development of new drugs.
Used in Chemical Synthesis:
In the field of chemical synthesis, 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride serves as a versatile building block for creating a wide range of chemical compounds. Its unique structure allows for various functional group transformations, making it a valuable asset in the synthesis of novel molecules with potential applications in different industries.

Upstream product

• 17413-10-4 2,3-dihydro-1,4-benzodioxin-6-ylmethylamine 
• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 31127-39-6 2,3-dihydrobenzo[b][1,4]dioxin-6-carbaldoxime 

Downstream Products

• 1175086-06-2 (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3-iodo-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amine 
• 1175086-30-2 (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3,5-dimethyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine 

Relevant articles and documents

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Sodium nitrite-catalyzed aerobic oxidative Csp2-Csp3 coupling: Direct construction of the 4-aryldihydroisoquinolinone moiety

A bioinspired approach for the construction of the 4- aryldihydroisoquinolinone moiety via direct oxidative Csp2-Csp 3 coupling has been developed, which uses inexpensive sodium nitrite as catalyst and environmentally benign oxygen in the air as terminal oxidant.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.