312-32-3

Basic information

• Product Name: 1-(4-Fluorophenylsulfonyl)piperidine
• Synonyms: 1-(4-Fluorophenylsulfonyl)piperidine
• CAS NO: 312-32-3
• Molecular Formula: C₁₁H₁₄FNO₂S
• Molecular Weight: 243.2977632
• Mol File: 312-32-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 352.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.287±0.06 g/cm3(Predicted)
• PKA: -4.87±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Fluorophenylsulfonyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenylsulfonyl)piperidine(312-32-3)
• EPA Substance Registry System: 1-(4-Fluorophenylsulfonyl)piperidine(312-32-3)

Safety Data

• Hazardous Substances Data: 312-32-3(Hazardous Substances Data)

Usage

General Description

1-(4-Fluorophenylsulfonyl)piperidine is a chemical compound with the molecular formula C11H14FNO2S. It is a white to off-white crystalline solid and is often used as an intermediate in the synthesis of pharmaceuticals. 1-(4-Fluorophenylsulfonyl)piperidine is commonly used in the development of new drugs, particularly in the field of medicinal chemistry. Its unique structure and properties make it a valuable building block for the creation of novel compounds with potential therapeutic applications. Additionally, it has been studied for its potential as a reagent and catalyst in organic synthesis. Overall, 1-(4-Fluorophenylsulfonyl)piperidine plays a significant role in the advancement of drug discovery and development.

Upstream product

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• 873-55-2 sodium benzenesulfonate 
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Relevant articles and documents

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

A novel strategy for installation of a sulfonyl fragment into arenes has been accomplished via an iron-catalyzed radical coupling reaction. Arene radicals derived from diaryliodoniums via single electron transfer reaction combine with sulfoxylate anion radicals readily generated from commercially available rongalite (HOCH2SO2Na·2H2O) to afford arylsulfinates efficiently at room temperature. In this protocol, a broad range of functional groups are tolerated to give products in good yields.

Substituted 2- (S) -hydroxy-3- (piperidin-4-yl-methylamino) -propyl ethers and substituted 2-aryl-2- (R) - hydroxy-1- (piperidin-4-yl-methyl) -ethylamine beta-3 adrenergic receptor agonists

This invention provides compounds of Formula I having the structure wherein A, B, Z, R and R1 are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.