312736-50-8

Basic information

• Product Name: 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE
• Synonyms: 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE;2-PyrazinecarboxaMide,3,5-dichloro-
• CAS NO: 312736-50-8
• Molecular Formula: C₅H₃Cl₂N₃O
• Molecular Weight: 192.01
• Mol File: 312736-50-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 299.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.620±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.99±0.50(Predicted)
• CAS DataBase Reference: 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE(312736-50-8)
• EPA Substance Registry System: 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE(312736-50-8)

Safety Data

• Hazardous Substances Data: 312736-50-8(Hazardous Substances Data)

Usage

General Description

3,5-Dichloropyrazine-2-carboxamide is a organic compound that falls under the category of pyrazines, which are bicyclic compounds containing a pyrazine ring. Pyrazines are found in diverse kinds of food and contribute to their flavor. The chemical formula for this compound is C5H2Cl2N2O, suggesting it consists of five carbon atoms, two hydrogen atoms, two chlorine atoms, two nitrogen atoms, and one oxygen atom. The role of this particular chemical is not widely recognized or studied, and records of its use are minimal. More research and study may be needed to fully understand the properties, safety, and potential uses of this chemical.

Upstream product

• 312736-49-5 3,5-dichloropyrazine-2-carboxylic acid 
• 4774-14-5 2,6-dichloropyrazine 
• 77287-34-4 formamide 

Downstream Products

• 313339-92-3 3,5-dichloro-pyrazine-2-carbonitrile 
• 136866-39-2 1-(3,5-dichloropyrazin-2-yl)ethan-1-one 
• 1314936-02-1 3,5-dichloro-2-ethylpyrazine 
• 313340-08-8 3,5-dichloro-6-ethylpyrazine-2-carboxamide 

Relevant articles and documents

Synthesis method of 3,5-dichloro-6-ethylpyrazineformamide

The invention discloses a synthetic method of 3,5-dichloro-6-ethylpyrazine formamide, and relates to the technical field of intermediate for synthesizing gilteritinib. The method is technically characterized by comprising the following steps: heating 2,6-dichloropyrazine and formamide to 70-130 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain 3,5-dichloropyrazine formamide; carrying out heating reflux on 3,5-dichloropyrazine formamide for 3-6 h under the action of a dehydrating agent, and synthesizing 3,5-dichloropyrazine formonitrile through dehydration; carrying out a Grignard reactionon the 3,5-dichloropyrazine formonitrile in an organic solvent A under the action of a methylation reagent to prepare 3,5-dichloro-2-acetylpyrazine; under theaction of an acidic catalyst and a silicon-hydrogen reducing agent, reducing the 3,5-dichloro-2-acetyl pyrazine in an organic solvent B to obtain 3,5-dichloro-2-ethyl pyrazine; and heating the 3,5-dichloro-2-ethyl pyrazine and formamide to 50-120 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain the 3,5-dichloro-6-ethylpyrazine formamide. According to the invention, the operation method is simple, the reaction conditions of the synthesis process are mild, the cost is reduced, and meanwhile high economic benefits can be brought.

CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.

Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof

The present invention relates to a novel imidazotriazinone or imidazopyrazinone derivatives, a tautomer thereof, a stereomer and a mixture thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating tankyrase-related diseases comprising the same as active components.COPYRIGHT KIPO 2016