31299-91-9

Basic information

• Product Name: 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole
• CAS NO: 31299-91-9
• Molecular Formula: C₆H₇Cl₂NS
• Molecular Weight: 196.0975
• Mol File: 31299-91-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 301.2°C at 760 mmHg
• Flash Point: 135.9°C
• Density: 1.356g/cm³
• Vapor Pressure: 0.00191mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole(31299-91-9)
• EPA Substance Registry System: 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole(31299-91-9)

Safety Data

• Hazardous Substances Data: 31299-91-9(Hazardous Substances Data)

Upstream product

• 58371-98-5 3, 5-dichloro-2-pentanone 
• 42261-30-3 thiazole, 2-hydroxy-4-methyl-5-(beta-chloroethyl)- 

Relevant articles and documents

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.