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313352-62-4

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313352-62-4 Usage

Description

(5R)-5-phenyl-2-Pyrrolidinone is a chiral pyrrolidinone derivative characterized by its (5R) configuration, where the substituent at the fifth carbon is in the R (rectus) configuration. (5R)-5-phenyl-2-Pyrrolidinone features a phenyl group attached to the fifth carbon of the pyrrolidinone ring, which imparts distinct chemical and biological properties. It is an important molecule in medicinal and synthetic chemistry due to its unique structure and properties.

Uses

Used in Chemical Synthesis:
(5R)-5-phenyl-2-Pyrrolidinone is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Industry:
(5R)-5-phenyl-2-Pyrrolidinone is used as a building block for the production of biologically active compounds, leveraging its unique structure to create new pharmaceutical agents with potential therapeutic applications.
Used in Medicinal Chemistry:
(5R)-5-phenyl-2-Pyrrolidinone is utilized in the field of medicinal chemistry for its potential to be incorporated into drug molecules, enhancing their efficacy and selectivity in targeting specific biological pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 313352-62-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,3,3,5 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 313352-62:
(8*3)+(7*1)+(6*3)+(5*3)+(4*5)+(3*2)+(2*6)+(1*2)=104
104 % 10 = 4
So 313352-62-4 is a valid CAS Registry Number.

313352-62-4Relevant articles and documents

Method for synthesizing chiral lactam through tandem reductive amination

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Paragraph 0082-0088; 0092, (2021/02/10)

The invention belongs to the technical field of chemical synthesis preparation, and particularly relates to a method for synthesizing chiral lactam through tandem reductive amination, which successfully realizes ruthenium-catalyzed asymmetric reductive amination/cyclization tandem reaction to efficiently construct chiral lactam by using substrates of keto acid and keto ester.

Iridium-Catalyzed Enantioselective C(sp3)-H Amidation Controlled by Attractive Noncovalent Interactions

Wang, Hao,Park, Yoonsu,Bai, Ziqian,Chang, Sukbok,He, Gang,Chen, Gong

supporting information, p. 7194 - 7201 (2019/05/10)

While remarkable progress has been made over the past decade, new design strategies for chiral catalysts in enantioselective C(sp3)-H functionalization reactions are still highly desirable. In particular, the ability to use attractive noncovalent interactions for rate acceleration and enantiocontrol would significantly expand the current arsenal for asymmetric metal catalysis. Herein, we report the development of a highly enantioselective Ir(III)-catalyzed intramolecular C(sp3)-H amidation reaction of dioxazolone substrates for synthesis of optically enriched γ-lactams using a newly designed α-amino-acid-based chiral ligand. This Ir-catalyzed reaction proceeds with excellent efficiency and with outstanding enantioselectivity for both activated and unactivated alkyl C(sp3)-H bonds under very mild conditions. It offers the first general route for asymmetric synthesis of γ-alkyl γ-lactams. Water was found to be a unique cosolvent to achieve excellent enantioselectivity for γ-aryl lactam production. Mechanistic studies revealed that the ligands form a well-defined groove-type chiral pocket around the Ir center. The hydrophobic effect of this pocket allows facile stereocontrolled binding of substrates in polar or aqueous media. Instead of capitalizing on steric repulsions as in the conventional approaches, this new Ir catalyst operates through an unprecedented enantiocontrol mechanism for intramolecular nitrenoid C-H insertion featuring multiple attractive noncovalent interactions.

Amino acid chiral ligand containing bidentate coordination group, chiral catalyst, and corresponding preparation methods and applications thereof

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Paragraph 0121-0125, (2019/10/02)

The present invention relates to an amino acid chiral ligand containing a bidentate coordination group, a chiral catalyst, and corresponding preparation methods and applications thereof. The chiral ligand is prepared from a cheap and easily available amino acid, and the development of the chiral ligand can improve the diversity of the chiral ligand. The chiral Ir (III) catalyst is simply and efficiently prepared from the chiral ligand only through a one-step reaction. The chiral Ir (III) catalyst is characterized in that a bidentate guiding group is introduced to an amino acid framework to change the original coordination mode of the amino acid and Ir in order to enhance the chiral control ability of the amino acid to the Ir(III) catalyst. The chiral Ir(III) catalyst is designed and synthesized for the first time, and the selectivity reaches up to 99% ee when the catalyst is successfully applied to the high-efficiency asymmetric synthesis of chiral gamma-cyclolactam, so the catalyst has superior stereo control ability.

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