3138-88-3

Basic information

• Product Name: (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine
• Synonyms: 1-BENZYL-2(R),5(S)-DIMETHYL-PIPERAZINE;trans-1-benzyl-2,5-dimethylpiperazine;(2R,5S)-rel-2,5-Dimethyl-1-(phenylmethyl)piperazine
• CAS NO: 3138-88-3
• Molecular Formula: C13H20N2
• Molecular Weight: 204.31
• Product Categories: Nitrogen cyclic compounds
• Mol File: 3138-88-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 292℃
• Flash Point: 110℃
• Appearance: /
• Density: 0.964
• Vapor Pressure: 0.00194mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine(3138-88-3)
• EPA Substance Registry System: (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine(3138-88-3)

Safety Data

• Hazardous Substances Data: 3138-88-3(Hazardous Substances Data)

Usage

General Description

(2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine is a chemical compound with the molecular formula C14H22N2. It is a piperazine derivative with a benzyl group and two methyl groups attached to the piperazine ring. (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine is commonly used as an intermediate in organic synthesis and pharmaceutical research. It may also have potential applications in the development of new drugs or materials. The specific properties and uses of (2R,5S)-1-Benzyl-2,5-Dimethyl-Piperazine will depend on further research and testing.

InChI:InChI=1/C13H20N2/c1-11-9-15(12(2)8-14-11)10-13-6-4-3-5-7-13/h3-7,11-12,14H,8-10H2,1-2H3/t11-,12+/m1/s1

Upstream product

• 100-39-0 benzyl bromide 
• 2815-34-1 2,5-dimethyl-piperazine 
• 3138-88-3 (+/-)-trans-2,5-dimethyl-4-benzyl-piperazine 
• 431062-00-9 4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 3744-87-4 Boc-(R)-Ala 
• 31022-10-3 N-benzyl-L-alanine methyl ester 
• 75-36-5 acetyl chloride 
• 200731-31-3 HATU 
• 3138-88-3 C₁₃H₂₀N₂ 
• 1072102-01-2 (3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione 
• 1072101-99-5 C₁₉H₂₈N₂O₅ 
• 1072102-00-1 C₁₄H₂₀N₂O₃*ClH 
• 159999-80-1 N-benzyl-N-Boc-L-alanine 
• 100-44-7 benzyl chloride 

Downstream Products

• 216532-43-3 (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine 
• 260254-80-6 trans-2R,5S-dimethyl-4-benzyl-piperazine 

Relevant articles and documents

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C

The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications (including in particular diabetic retinopathy, nephropathy or neuropathy), cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, viral diseases, inflammatory disorders, or diseases in which the liver is a target organ

Indole-type derivatives as inhibitors of p38 kinase

The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein represents a single or double bond;one Z2 is CA or CR8A and the other is CR1, CR12, NR6 or N wherein each R1, R6 and R8 is independently hydrogen or noninterfering substituent;A is —Wi—COXjY wherein Y is COR2 or an isostere thereof and R2 is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2-6 ?, and each of i and j is independently 0 or 1;as Z3 is NR7 or O;each R3 is independently a noninterfering substituent;n is 0-3;each of L1 and L2 is a linker;each R4 is independently a noninterfering substituent;m is 0-4;Z1 is CR5 or N wherein R5 is hydrogen or a noninterfering substituent;each of 1 and k is an integer from 0-2 wherein the sum of 1 and k is 0-3;Ar is an aryl group substituted with 0-5 noninterfering substituents, wherein two noninterfering substituents can form a fused ring; andthe distance between the atom of Ar linked to L2 and the center of the α ring is 4.5-24 ?.