3158-80-3

Basic information

• Product Name: 8-chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one
• Synonyms: 8-chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one
• CAS NO: 3158-80-3
• Molecular Formula: C₁₃H₈ClNOS
• Molecular Weight: 261.72672
• Mol File: 3158-80-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one(3158-80-3)
• EPA Substance Registry System: 8-chlorodibenzo[b,f][1,4]thiazepin-11(10H)-one(3158-80-3)

Safety Data

• Hazardous Substances Data: 3158-80-3(Hazardous Substances Data)

Upstream product

• 93535-13-8 2-(2-amino-4-chloro-phenylsulfanyl)-benzoic acid methyl ester 
• 167996-98-7 2-(2-amino-4-chlorophenylsulfanyl)benzoic acid 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 92161-65-4 methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate 
• 126395-03-7 2-(4-chloro-2-nitrophenylsulfanyl)benzoic acid 
• 4892-02-8 Methyl thiosalicylate 
• 17999-25-6 methyl thiosalicylate 
• 89-61-2 2,5-dichloronitrobenzene 

Downstream Products

• 87213-27-2 8-chlorodibenzo-1,4-thiazepin-11(10H)-thione 
• 87213-29-4 8-chloro-11-hydrazinodibenzo-1,4-thiazepine 
• 87213-32-9 6-chlorodibenzo-1,2,4-triazolo<4,3-d>-1,4-thiazepine 

Relevant articles and documents

PROCESS FOR PREPARATION OF DIBENZOTHIAZEPINONE COMPOUNDS

The present invention discloses a process for the preparation of dibenzothiazepinone compounds of Formula I. The process for preparation of a dibenzothiazepinone compound of Formula I comprises reaction of compound of formula II in the presence of an acid catalyst comprising phosphorus pentoxide and methanesulfonic acid. The dibenzothiazepinone compounds of Formula I are key intermediate for the preparation of 2-(2-(4-dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol known as quetiapine and its derivatives, which are effective antipsychotic substances.

AMINO SUBSTITUTED DIARYL[A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.

Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NM