316810-08-9

Basic information

• Product Name: Benzoic acid, 4-cyano-2-ethoxy-
• CAS NO: 316810-08-9
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol File: 316810-08-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-cyano-2-ethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-cyano-2-ethoxy-(316810-08-9)
• EPA Substance Registry System: Benzoic acid, 4-cyano-2-ethoxy-(316810-08-9)

Safety Data

• Hazardous Substances Data: 316810-08-9(Hazardous Substances Data)

Upstream product

• 59-07-4 2-ethoxy-4-aminobenzoic acid 
• 544-92-3 copper(I) cyanide 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 
• 2486-55-7 methyl 2-ethoxy-4-acetamidobenzoate 

Downstream Products

• 316810-09-0 2-ethoxy-4-cyanobenzoyl chloride 
• 910568-52-4 4-cyano-2-ethoxybenzoic acid methyl ester 
• 316810-13-6 N-(2-amino-4,5-dichlorophenyl)-2-ethoxy-4-cyanobenzamide 

Relevant articles and documents

4,4,5,5, Tetrasubstituted imidazolines

There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.

Azolylbenzamides and analogues and their use for treating osteoporosis

A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: X represents oxygen, sulphur, or NRb; Y and Z each independently represent nitrogen, CH, CR1 or CR2; A represents an unsubstituted or substituted aryl group or an unsubstituted or substituted heterocyclyl group; Ra represents —C(O)NRsRt; R1 and R2 each independently represents hydrogen or specific substituents; and the use of such a compound in the treatment and/or prophylaxis of diseases associated with over activity of osteoclasts in mammals.

Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase

Amides of (2Z,4E)-5-[(5,6-dichloroindol-2-yl)]-2-methoxy-N-[3-[4-[3-(carboxymethoxy) phenyl)] piperazin-1-yl]propyl]-2,4-pentadienamide (1) and of 5-(5,6-dichloro-2-indolyl)-2-methoxy-2,4-pentadienoic acid (2) are strong inhibitors of the vacuolar ATPase located on the plasma membrane of osteoclasts. In order to understand which V-ATPase subunit is involved in the interaction with these novel inhibitors, analogues containing a photoactivable group and an iodine atom were designed. A series of alcohols or amines containing the photoactivable trifluoroaziridinophenyl or benzophenone moiety and an iodine atom were linked to the above acids via an ester or amide group. These compounds could be thereafter used as a radioactive photoprobe to label the protein. Whereas the compounds containing the photoactivable groups maintained good inhibitory activity, the introduction of the bulky iodine atom was generally detrimental, decreasing potency significantly. Better results were obtained by linking 3-(4-aminopiperidinomethyl)-3′-iodobenzophenone to 3-ethoxy-4-(2-(5,6-dichlorobenzimidazolyl))benzoic acid to give the corresponding amide 27, that inhibited vacuolar ATP-ase with a IC50=140 nM. The feasibility of introducing a radioactive 125I atom was ascertained by exchanging the iodine with a tributylstannyl group, that was again substituted by iodine.