59-07-4

Basic information

• Product Name: Benzoic acid, 4-amino-2-ethoxy-
• Synonyms: 2-Aethoxy-4-amino-benzoesaeure;Benzoic acid,4-amino-2-ethoxy;2-Ethoxy-4-amino-benzoesaeure;2-ethoxy-4-aminobenzoic acid
• CAS NO: 59-07-4
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Mol File: 59-07-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 150-151 °C (decomp)
• Boiling Point: 371.9±27.0 °C(Predicted)
• Density: 1.251±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 4-amino-2-ethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-amino-2-ethoxy-(59-07-4)
• EPA Substance Registry System: Benzoic acid, 4-amino-2-ethoxy-(59-07-4)

Safety Data

• Hazardous Substances Data: 59-07-4(Hazardous Substances Data)

Upstream product

• 4136-97-4 methyl 4-aminosalicylate 
• 65-49-6 4-Aminosalicylic acid 
• 910572-96-2 2-ethoxy-4-nitro-benzoic acid ethyl ester 
• 619-19-2 2-hydroxy-4-nitrobenzoic acid 
• 2486-55-7 methyl 2-ethoxy-4-acetamidobenzoate 
• 2486-66-0 2-ethoxy-4-nitrobenzoic acid 
• 59-06-3 methyl 4-acetamido-2-ethoxybenzoate 

Downstream Products

• 2486-68-2 4-acetylamino-2-ethoxy-benzoic acid 
• 100800-71-3 2-ethoxy-4-amino-benzoic acid-(2-dimethylamino-ethyl ester) 
• 316810-08-9 2-ethoxy-4-cyanobenzoic acid 
• 958227-62-8 4-[4-((1R,2S)-2-isopropylcarbamoyl-cyclopentylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-2-ethoxybenzoic acid 

Relevant articles and documents

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography

Despite its implication in several physiological and pathological processes the serotonin subtype-4 receptor (5-HT4R) has seen limited effort for the development of radiolabeling agent especially concerning single photon emission computed tomography (SPECT). Bearing an ester function, the available ligands are rapidly susceptible to hydrolysis which limits their use in vivo. In this study the synthesis of iodinated benzamide and ketone analogs were described. Their affinity for the 5-HT4R and their lipophilicity were evaluated and the most promising derivatives were evaluated ex vivo for their binding to the receptor and for their ability to displace the reference ligand [125I]-SB207710.

4,4,5,5, Tetrasubstituted imidazolines

There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.

Azolylbenzamides and analogues and their use for treating osteoporosis

A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: X represents oxygen, sulphur, or NRb; Y and Z each independently represent nitrogen, CH, CR1 or CR2; A represents an unsubstituted or substituted aryl group or an unsubstituted or substituted heterocyclyl group; Ra represents —C(O)NRsRt; R1 and R2 each independently represents hydrogen or specific substituents; and the use of such a compound in the treatment and/or prophylaxis of diseases associated with over activity of osteoclasts in mammals.