31697-11-7Relevant articles and documents
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity
Coumar, Mohane Selvaraj,Leou, Jiun-Shyang,Shukla, Paritosh,Wu, Jian-Sung,Dixit, Ajay Kumar,Lin, Wen-Hsing,Chang, Chun-Yu,Lien, Tzu-Wen,Tan, Uan-Kang,Chen, Chun-Hwa,Hsu, John T.-A.,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang
experimental part, p. 1050 - 1062 (2009/12/24)
Aurora kinases have emerged as attractive targets for the design of anticancer drugs. Through structure- based virtual screening, novel pyrazole hit 8a was identified as Aurora kinase A inhibitor (IC50 = 15.1 μM). X-ray cocrystal structure of 8