31698-56-3

Basic information

• Product Name: Quinoline, 8-fluoro-4-Methyl-
• Synonyms: Quinoline, 8-fluoro-4-Methyl-;8-Fluoro-4-methylquinoline
• CAS NO: 31698-56-3
• Molecular Formula: C10H8FN
• Molecular Weight: 161.1756232
• Mol File: 31698-56-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Quinoline, 8-fluoro-4-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 8-fluoro-4-Methyl-(31698-56-3)
• EPA Substance Registry System: Quinoline, 8-fluoro-4-Methyl-(31698-56-3)

Safety Data

• Hazardous Substances Data: 31698-56-3(Hazardous Substances Data)

Usage

General Description

Quinoline, 8-fluoro-4-methyl- is a chemical compound with the molecular formula C10H8FN. It is a derivative of quinoline, a heterocyclic aromatic compound. This particular derivative is characterized by the presence of a fluorine atom at the 8th position and a methyl group at the 4th position on the quinoline ring. Quinoline, 8-fluoro-4-methyl- is used in various applications, including in the synthesis of pharmaceuticals and agrochemicals. It is known for its potential biological activity and is a subject of interest in medicinal chemistry research. The compound's unique structure and properties make it relevant in the development of new drugs and other biologically active molecules.

Upstream product

• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 348-54-9 2-Fluoroaniline 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 496792-30-4 8-fluoro-4-quinolinecarboxaldehyde 

Relevant articles and documents

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

The proteasome plays a crucial role in degradation of normal proteins that happen to be constitutively or inducibly unstable, and in this capacity it plays a regulatory role. Additionally, it degrades abnormal/damaged/mutant/misfolded proteins, which serves a quality-control function. Inhibitors of the proteasome have been validated in the treatment of multiple myeloma, with several FDA-approved therapeutics. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. A fragment-based drug discovery (FBDD) approach was utilized to identify fragments with activity against Rpn11. Screening of a library of metal-binding pharmacophores (MBPs) revealed that 8-thioquinoline (8TQ, IC50 value ～2.5 μM) displayed strong inhibition of Rpn11. Further synthetic elaboration of 8TQ yielded a small molecule compound (35, IC50 value ～400 nM) that is a potent and selective inhibitor of Rpn11 that blocks proliferation of tumor cells in culture.

QU1NOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA

The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.

AN IMPROVED PROCESS FOR THE SYNTHESIS OF QUINOLINE DERIVATIVES

The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anilines using two different catalysts, ferric chloride and zinc chloride in a one-pot set up reaction.