317319-21-4 Usage
Description
ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE, with the chemical name CAS# 317319-21-4, is a white crystalline solid that serves as a valuable compound in the realm of organic synthesis. Its unique molecular structure, featuring a thiazole ring with a fluorinated phenyl group and a trifluoromethyl substituent, endows it with potential reactivity and versatility in chemical reactions.
Uses
Used in Organic Synthesis:
ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE is used as a synthetic intermediate for the creation of various organic compounds. Its presence in the synthesis process allows for the development of new molecules with specific properties and applications across different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE is utilized as a building block for the synthesis of novel drug candidates. Its unique structure can contribute to the discovery of new therapeutic agents with improved pharmacological profiles.
Used in Agrochemical Industry:
ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE is also employed in the agrochemical industry as a precursor for the development of new pesticides and herbicides. Its chemical properties can be leveraged to create effective compounds for crop protection and management.
Used in Material Science:
In the field of material science, ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE is used as a component in the synthesis of advanced materials. Its incorporation can lead to the development of materials with enhanced properties, such as improved stability, conductivity, or other desirable characteristics.
Used in Dye and Pigment Industry:
ETHYL 2-[3-FLUORO-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-THIAZOLE-5-CARBOXYLATE is utilized in the dye and pigment industry for the synthesis of new colorants and dyes. Its chemical structure can contribute to the creation of dyes with unique color profiles and improved performance in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 317319-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,7,3,1 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 317319-21:
(8*3)+(7*1)+(6*7)+(5*3)+(4*1)+(3*9)+(2*2)+(1*1)=124
124 % 10 = 4
So 317319-21-4 is a valid CAS Registry Number.
317319-21-4Relevant articles and documents
Synthesis and Evaluation of PPARδAgonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis
Kress, Brian J.,Kim, Dong Hyun,Mayo, Jared R.,Farris, Jeffery T.,Heck, Benjamin,Sarver, Jeffrey G.,Andy, Divya,Trendel, Jill A.,Heck, Bruce E.,Erhardt, Paul W.
, p. 6996 - 7032 (2021/05/29)
We synthesized a directed library of compounds to explore the structure-activity relationships of peroxisome proliferator-activated receptor δ(PPARδ) activation relative to mesenchymal stem cell (MSC) osteogenesis. Our scaffold used para-substituted cinnamic acids as a polar headgroup, a heteroatom and heterocycle core connecting units, and substituted phenyl groups for the lipophilic tail. Compounds were screened for their ability to increase osteogenesis in MSCs, and the most promising were examined for subunit specificity using a quantitative PPAR transactivation assay. Six compounds were selected for in vivo studies in an ovariectomized mouse model of human postmenopausal osteoporosis. Four compounds improved bone density in vivo, with two (12d and 31a) having activity comparable to that of GW0742, a well-studied PPARδ-selective agonist. 31a (2-methyl-4-[N-methyl-N-[5-methylene-4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole]]aminocinnamic acid) had the highest selectivity for PPARδcompared to other subtypes, its selectivity far exceeding that of GW0742. Our results confirm that PPARδis a new drug target for possible treatment of osteoporosis via in situ manipulation of MSCs.
