317319-33-8 Usage
Description
2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-chloromethyl Thiazole (CAS# 317319-33-8) is a synthetic organic compound characterized by its unique molecular structure and chemical properties. It is a yellow oil at room temperature, indicating its lipophilic nature and potential for use in various chemical reactions and applications.
Uses
Used in Organic Synthesis:
2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-chloromethyl Thiazole is used as a key intermediate in organic synthesis for the development of pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and functional groups make it a versatile building block for creating complex molecules with specific biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-chloromethyl Thiazole is used as a starting material or a synthetic intermediate for the production of various drug candidates. Its presence in the molecular structure can impart specific pharmacological properties, such as improved potency, selectivity, or bioavailability, making it a valuable component in drug discovery and development.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, this compound is utilized as a precursor in the synthesis of novel pesticides, herbicides, or insecticides. Its incorporation into these molecules can enhance their efficacy, selectivity, or environmental stability, contributing to the development of more effective and sustainable agricultural solutions.
Used in Specialty Chemicals:
2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-chloromethyl Thiazole also finds applications in the production of specialty chemicals, such as dyes, pigments, or advanced materials. Its unique chemical properties can contribute to the development of innovative products with improved performance characteristics or novel functionalities.
Check Digit Verification of cas no
The CAS Registry Mumber 317319-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,7,3,1 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 317319-33:
(8*3)+(7*1)+(6*7)+(5*3)+(4*1)+(3*9)+(2*3)+(1*3)=128
128 % 10 = 8
So 317319-33-8 is a valid CAS Registry Number.
317319-33-8Relevant articles and documents
Synthesis and Evaluation of PPARδAgonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis
Kress, Brian J.,Kim, Dong Hyun,Mayo, Jared R.,Farris, Jeffery T.,Heck, Benjamin,Sarver, Jeffrey G.,Andy, Divya,Trendel, Jill A.,Heck, Bruce E.,Erhardt, Paul W.
, p. 6996 - 7032 (2021/05/29)
We synthesized a directed library of compounds to explore the structure-activity relationships of peroxisome proliferator-activated receptor δ(PPARδ) activation relative to mesenchymal stem cell (MSC) osteogenesis. Our scaffold used para-substituted cinnamic acids as a polar headgroup, a heteroatom and heterocycle core connecting units, and substituted phenyl groups for the lipophilic tail. Compounds were screened for their ability to increase osteogenesis in MSCs, and the most promising were examined for subunit specificity using a quantitative PPAR transactivation assay. Six compounds were selected for in vivo studies in an ovariectomized mouse model of human postmenopausal osteoporosis. Four compounds improved bone density in vivo, with two (12d and 31a) having activity comparable to that of GW0742, a well-studied PPARδ-selective agonist. 31a (2-methyl-4-[N-methyl-N-[5-methylene-4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole]]aminocinnamic acid) had the highest selectivity for PPARδcompared to other subtypes, its selectivity far exceeding that of GW0742. Our results confirm that PPARδis a new drug target for possible treatment of osteoporosis via in situ manipulation of MSCs.