317338-52-6

Basic information

• Product Name: Cyclohexanone, 4-(1H-imidazol-5-ylmethyl)-
• Synonyms: Cyclohexanone, 4-(1H-imidazol-5-ylmethyl)-
• CAS NO: 317338-52-6
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Mol File: 317338-52-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexanone, 4-(1H-imidazol-5-ylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(1H-imidazol-5-ylmethyl)-(317338-52-6)
• EPA Substance Registry System: Cyclohexanone, 4-(1H-imidazol-5-ylmethyl)-(317338-52-6)

Safety Data

• Hazardous Substances Data: 317338-52-6(Hazardous Substances Data)

Upstream product

• 317338-50-4 5-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-1H-imidazole 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 51656-91-8 ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate 
• 62141-26-8 ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate 
• 135761-76-1 2-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol 
• 143948-97-4 8-formylethyl-1,4-dioxaspiro<4.5>decane 
• 317338-50-4 C₁₂H₁₈N₂O₂ 
• 317338-46-8 methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate 
• 172270-85-8 8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane 

Downstream Products

• 869501-10-0 4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester 
• 869501-11-1 4-(4-hydroxycyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester 
• 869501-12-2 4-(4-aminocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester 
• 869501-03-1 4-(1H-imidazol-5-ylmethyl)cyclohexylamine dihidrobromide 
• 317339-33-6 C₁₂H₁₉N₃O₃S 

Relevant articles and documents

New high affinity H3 receptor agonists without a basic side chain

In this study, we replaced the basic amine function of the known histamine H3 receptor agonists imbutamine or immepip with non-basic alcohol or hydrocarbon moieties. All compounds in this study show a moderate to high affinity for the cloned human H3 receptor and, unexpectedly, almost all of them act as potent agonists. Moreover, in the alcohol series, we consistently observed an increased selectivity for the human H3 receptor over the human H4 receptor, but none of the compounds in this series possess increased affinity and functional activity compared to their alkylamine congeners. In this new series of compounds VUF5657, 5-(1H-imidazol-4-yl)-pentan-1-ol, is the most potent histamine H3 receptor agonist (pKi = 8.0 and pEC50 = 8.1) with a 320-fold selectivity at the human H3 receptor over the human H 4 receptor.