31753-17-0 Usage
Description
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of Prostaglandin E2 (PGE2), a bioactive lipid compound derived from arachidonic acid. It is one of the primary cyclooxygenase products and has been extensively studied for its various biological activities. PGE2 plays a significant role in regulating inflammation, fertility, parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are mediated through at least four distinct receptors, namely EP1, EP2, EP3, and EP4, with affinity constants (Kd) values ranging from 1-10 nM depending on the receptor subtype and tissue.
Uses
Used in Pharmaceutical Industry:
Prostaglandin E2 methyl ester is used as a therapeutic agent for various medical conditions due to its influence on inflammation, fertility, and immune modulation. Its enhanced lipid solubility compared to the native PGE2 allows for better absorption and bioavailability, making it a valuable compound in the development of pharmaceutical products.
Used in Research and Development:
PGE2 methyl ester is utilized as a research tool in the study of the biological effects of prostaglandins. Its interaction with the four distinct receptors (EP1, EP2, EP3, and EP4) provides valuable insights into the mechanisms of action and potential therapeutic applications of prostaglandins in various physiological and pathological processes.
Used in Inflammation Management:
Prostaglandin E2 methyl ester is used as an anti-inflammatory agent, particularly in conditions where the modulation of inflammation is crucial for disease management. Its ability to influence the immune response and reduce inflammation makes it a potential candidate for the treatment of various inflammatory disorders.
Used in Fertility and Parturition:
PGE2 methyl ester is employed in the management of fertility and parturition due to its role in regulating these processes. It can be used to facilitate the onset of labor or to maintain pregnancy in cases where it is necessary to prevent preterm labor.
Used in Gastric Mucosal Integrity:
Prostaglandin E2 methyl ester is used to protect and maintain the integrity of the gastric mucosa. Its influence on gastric mucosal cells helps to prevent damage and promote healing, making it a potential therapeutic option for conditions such as gastritis and peptic ulcers.
Check Digit Verification of cas no
The CAS Registry Mumber 31753-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,5 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31753-17:
(7*3)+(6*1)+(5*7)+(4*5)+(3*3)+(2*1)+(1*7)=100
100 % 10 = 0
So 31753-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H34O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-18,20,22,24H,3-4,6-7,9-12,15H2,1-2H3/b8-5+,14-13+/t16-,17+,18+,20+/m0/s1
31753-17-0Relevant articles and documents
Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries
Chen, Shaoqing,Janda, Kim D.
, p. 8724 - 8725 (1997)
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Novel and flexible entries into prostaglandins and analogues based on ring closing alkyne metathesis or alkyne cross metathesis
Furstner,Grela,Mathes,Lehmann
, p. 11799 - 11805 (2007/10/03)
The suitably functionalized cyclopentanone derivatives 12, 13, 19, and 37 serve as common precursors for the synthesis of various prostaglandins, prostaglandin-1,15-lactones, and unnatural analogues thereof. All of them contain a 2-butynyl entity which is
Enantioselective Rh-Mediated Synthesis of (-)-PGE2 Methyl Ester
Taber, Douglass F.,Hoerrner, R. Scott
, p. 441 - 447 (2007/10/02)
Intramolecular Rh(II) carboxylate catalyzed cyclization of an α-diazo β-methylene ketone to form a fused cyclopropane is shown to compete efficiently with β-hydride elimination, so long as a catalyst derived from an electron-donating carboxylate is used.C
