50781-91-4 Usage
Description
Methyl-7-hydroxyhept-5-ynoate, also known as 7-Hydroxy-5-heptynoic Acid Methyl Ester, is an organic compound that serves as a crucial intermediate in the synthesis of Tianeptine (T436800). Tianeptine is a molecule with various pharmacological properties, including psychostimulant, anti-ulcer, and anti-emetic effects. Methyl-7-hydroxyhept-5-ynoate is characterized by its unique molecular structure, which contributes to its role in the development of Tianeptine and its subsequent applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Methyl-7-hydroxyhept-5-ynoate is used as an intermediate in the synthesis of Tianeptine for its psychostimulant, anti-ulcer, and anti-emetic properties. Methyl-7-hydroxyhept-5-ynoate plays a vital role in the production of Tianeptine, which is known to modulate the serotonin system in the brain, providing relief from various conditions such as depression, anxiety, and gastrointestinal issues.
Used in Antidepressant Applications:
As a component in the synthesis of Tianeptine, Methyl-7-hydroxyhept-5-ynoate contributes to the development of antidepressant medications. Tianeptine, the final product, is known to have a unique mechanism of action that involves the selective reuptake inhibition of serotonin, making it an effective treatment for depression and related disorders.
Used in Anti-ulcer Applications:
Methyl-7-hydroxyhept-5-ynoate is also used in the development of anti-ulcer medications. Tianeptine, synthesized using this intermediate, has been shown to exhibit anti-ulcer properties, providing relief from gastrointestinal ulcers and promoting healing in the stomach lining.
Used in Anti-emetic Applications:
In addition to its antidepressant and anti-ulcer properties, Methyl-7-hydroxyhept-5-ynoate is utilized in the synthesis of anti-emetic medications. Tianeptine, the final product, has been found to be effective in managing nausea and vomiting, making it a valuable asset in the treatment of various conditions that cause these symptoms, such as chemotherapy-induced nausea and motion sickness.
Check Digit Verification of cas no
The CAS Registry Mumber 50781-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,7,8 and 1 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 50781-91:
(7*5)+(6*0)+(5*7)+(4*8)+(3*1)+(2*9)+(1*1)=124
124 % 10 = 4
So 50781-91-4 is a valid CAS Registry Number.
50781-91-4Relevant articles and documents
Corey,E.J.,Sachdev,H.S.
, p. 8483 - 8484 (1973)
Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs
Barnych, Bogdan,Rand, Amy A.,Cajka, Tomas,Lee, Kin Sing Stephen,Hammock, Bruce D.
supporting information, p. 4308 - 4313 (2017/07/10)
COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and furth
Discovery of an 8-aza-5-thiaProstaglandin E1 analog as a highly selective EP4 receptor agonist
Kambe, Tohru,Maruyama, Toru,Naganawa, Atsushi,Asada, Masaki,Seki, Akiteru,Maruyama, Takayuki,Nakai, Hisao,Toda, Masaaki
experimental part, p. 1494 - 1508 (2012/01/13)
For the purpose of discovering an orally available EP4 subtype-selective agonist, a series of 8-aza prostaglandin E1 (PGE1) analogs were synthesized and evaluated for their affinity for PGE2 receptor subtypes. Additionally
A simplified synthesis of the diastereomers of Levuglandin E2
Amarnath, Venkataraman,Amarnath, Kalyani,Masterson, Tina,Davies, Sean,Roberts II, Jackson
, p. 397 - 408 (2007/10/03)
We report a synthesis of Levuglandin E2, as a mixture of easily separable diastereomers (15-E2-isoketals). The key feature is the protection of its reactive aldehyde as dimethyl acetal, which is introduced with 2,2-dimethoxyethanal and removed in minutes with Montmorillonite K-10. The synthesis could be modified to the preparation of 15-E2-isoketals with stable isotopes or with radiolabels. Copyright Taylor & Francis, Inc.
