318-49-0

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]-
• CAS NO: 318-49-0
• Molecular Formula: C15H10FNO2
• Molecular Weight: 255.248
• Mol File: 318-49-0.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]-(318-49-0)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]-(318-49-0)

Safety Data

• Hazardous Substances Data: 318-49-0(Hazardous Substances Data)

Usage

Psychoactive Drug

Fluspidine has mind-altering effects and is used to treat various mental health conditions.

Anxiolytic Properties

Fluspidine helps in reducing anxiety symptoms and promoting a sense of well-being.

Antipsychotic Properties

The compound exhibits properties that help in managing and treating symptoms of psychosis, such as hallucinations and delusions.

Sigma Receptor Agonist

Fluspidine acts on sigma receptors in the brain, which are involved in various neurological processes, including mood regulation and sensory perception.

Potential Use

Fluspidine has been studied for its potential use in treating anxiety, schizophrenia, and depression.

Neurotransmitter Modulation

The compound is believed to modulate the release of neurotransmitters like dopamine, serotonin, and glutamate, which may contribute to its therapeutic effects.

Further Research Needed

More studies are required to fully understand the pharmacological mechanisms and clinical applications of fluspidine, indicating that its use in treating mental health conditions is still being explored.

Upstream product

• 85-44-9 phthalic anhydride 
• 140-75-0 para-fluorobenzylamine 
• 496-12-8 isoindoline 
• 459-46-1 4-Fluorobenzyl bromide 
• 612-14-6 phthalyl alcohol 
• 462-06-6 fluorobenzene 
• 53478-64-1 2-(aminomethyl)isoindoline-1,3-dione 
• 136918-14-4 phthalimide 
• 83-33-0 inden-1-one 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 524-38-9 N-hydroxyphthalimide 
• 210422-66-5 4-fluorobenzaldehyde p-toluenesulfonylhydrazone 
• 459-57-4 4-fluorobenzaldehyde 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 140-75-0 para-fluorobenzylamine 
• 935686-74-1 3-(2-[1,3]dioxolan-2-ylethyl)-2-(4-fluorobenzyl)-3-hydroxy-2,3-dihydroisoindol-1-one 
• 612-14-6 phthalyl alcohol 
• 21244-24-6 2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione 
• 1383549-86-7 3-(4-fluorophenyl)isoquinoline 

Relevant articles and documents

Graphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions

An environmentally friendly, inexpensive, carbocatalyst, graphene oxide (GO) promoted efficient, metal-free transamidation of various carboxamides with aliphatic, cyclic, and aromatic amines is demonstrated. The protocol is equally applicable to phthalimide, urea, and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (?C=O), epoxy (?O?), carboxyl (?COOH) and hydroxyl (?OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products in good to excellent yields. The one-pot synthesis of 2,3-Dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramolecular transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity. (Figure presented.).

Visible-Light-Mediated Efficient Metal-Free Catalyst for α-Oxygenation of Tertiary Amines to Amides

A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to the corresponding amides using oxygen as an oxidant. This visible-light-mediated oxygenation reaction exhibited excellent substrates scope under mild reaction conditions and generated water as the only byproduct. The synthetic utility of this approach has been demonstrated by applying onto drug molecules. At the end, detailed mechanistic reactions clearly showed the role of oxygen and the photocatalyst.

COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME

Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycoside, to treat diseases or disorders ameliorated by modulation of a premature termination codon (PTC) of an RNA molecule in a translation system. The disorder or disease may be Dystrophic epidermolysis bullosa, Batten disease, Duchenne muscular dystrophy, cancer, and spinal muscular atrophy. Ar-L-B (I)