31803-00-6 Usage
Description
5-Benzyl-1,3,4-oxadiazol-2-amine is a synthetic organic compound characterized by its unique oxadiazol structure. It is a versatile intermediate in the field of medicinal chemistry and drug development, known for its potential to form stable and bioactive molecules. Its chemical properties allow it to be easily integrated into various molecular frameworks, making it a valuable building block for the creation of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
5-Benzyl-1,3,4-oxadiazol-2-amine is used as a key intermediate in the synthesis of 6,7-dimethoxyquinazoline derivatives. These derivatives are of significant interest due to their potential as VEGFR-2 tyrosine kinase inhibitors. The inhibition of VEGFR-2 is a crucial strategy in the development of anticancer agents, as it targets the vascular endothelial growth factor receptor-2, which plays a critical role in tumor angiogenesis and growth.
In the context of cancer treatment, 5-benzyl-1,3,4-oxadiazol-2-amine contributes to the development of potential anticancer agents by facilitating the creation of molecules that can effectively target and inhibit VEGFR-2 activity. This, in turn, can lead to the suppression of tumor blood vessel formation and ultimately inhibit the growth and spread of cancer cells. The use of this compound in the pharmaceutical industry highlights its importance in advancing the discovery and synthesis of new and effective cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 31803-00-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,8,0 and 3 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 31803-00:
(7*3)+(6*1)+(5*8)+(4*0)+(3*3)+(2*0)+(1*0)=76
76 % 10 = 6
So 31803-00-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H9N3O/c10-9-12-11-8(13-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,10,12)
31803-00-6Relevant articles and documents
Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination
Yan, Longjia,Deng, Minggao,Chen, Anchao,Li, Yongliang,Zhang, Wanzheng,Du, Zhi-yun,Dong, Chang-zhi,Meunier, Bernard,Chen, Huixiong
supporting information, p. 1359 - 1362 (2019/04/25)
An efficient and practical procedure was developed to prepare various N-pyrimidin[1,3,4]oxadiazole and thiadiazole scaffolds using a Buchwald-type coupling. The products of this reaction are otherwise difficult to access and could be used as building bloc
A convenient synthesis of 5-substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using iodine and Oxone
Shinde, Vikas N.,Ugarkar, Bheemarao G.,Ghorpade, Sandeep R.
, p. 53 - 54 (2013/04/10)
A convenient methodology has been developed for the synthesis of substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using catalytic amount of iodine/KI in the presence of Oxone as a bulk oxidant. This offers the adv
Synthesis and Biological Activity of 2-Substituted 6-Carbethoxy-5(H)-oxo-1,3,4-oxadiazolopyrimidines
Murty, M. S. R.,Ramalingam, T.,Diwan, P. V.,Sattur, P. B.
, p. 293 - 294 (2007/10/02)
Several 2-substituted 6-carbethoxy-5(H)-oxo-1,3,4-oxadiazolopyrimidines (4) have been synthesised by the reaction of 5-substituted 2-amino-1,3,4-oxadiazoles (1) with diethyl ethoxymethylenemalonate (2).These compounds have been screened for their p
