35604-35-4

Basic information

• Product Name: 5-benzyl-1,2,4-oxadiazol-3-amine
• Synonyms: 5-benzyl-1,2,4-oxadiazol-3-amine
• CAS NO: 35604-35-4
• Molecular Weight: 175.19
• Mol File: 35604-35-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-benzyl-1,2,4-oxadiazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-1,2,4-oxadiazol-3-amine(35604-35-4)
• EPA Substance Registry System: 5-benzyl-1,2,4-oxadiazol-3-amine(35604-35-4)

Safety Data

• Hazardous Substances Data: 35604-35-4(Hazardous Substances Data)

Upstream product

• 52770-96-4 (phenylacetyl)cyanamide 
• 171006-93-2 3-phenylacetylamino-4-phenylfurazan 

Downstream Products

• 22819-07-4 3-Amino-5-benzyl-1H-1,2,4-triazole 
• 1257878-63-9 3-chloro-5-benzyl-1,2,4-oxadiazole 
• 266327-99-5 N-(1-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-1H-[1,2,4]triazol-3-yl)-2-phenyl-acetamide 
• 266327-98-4 N-[1-(4-{[(2R)-3-(acetylamino)-2-hydroxypropyl]amino}-2-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-phenylacetamide 
• 266327-97-3 N-({(5S)-3-[4-({[(5-benzyl-1,2,4-oxadiazol-3-yl)imino]methyl}amino)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide 
• 266327-95-1 ethyl 5-benzyl-1,2,4-oxadiazol-3-yliminoformate 
• 31803-00-6 5-benzyl-2-amino-1,3,4-oxadiazole 
• 52770-93-1 3-(5-benzyl-[1,2,4]oxadiazol-3-ylamino)-2-cyano-acrylic acid ethyl ester 
• 52770-94-2 N'-(5-benzyl-[1,2,4]oxadiazol-3-yl)-N,N-dimethyl-formamidine 

Relevant articles and documents

Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors

Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.

DERIVATIVES OF OXADIAZOLE AND PYRIDAZINE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

The invention relates to compounds of formula (I): in which: n is equal to 0 or 1; D represents an oxygen atom or a bond; W represents a nitrogen atom or a -CH- group; X1 represents a nitrogen atom or a -CH=CH- group; X2 represents an oxygen atom or a nitrogen atom; X3 represents an oxygen atom or a nitrogen atom; one of X1, X2, X3 being other than a nitrogen atom, X2 and X3 not being an oxygen atom at the same time; R1, R2 are absent or represent, (i) independently of one another, a hydrogen atom or a (C1 -C4)alkyl group, (ii) R1 and R2 may form, with the carbon atom to which they are attached, a -(C3-C10)cycloalkyl- group; Y represents a -(C3-C10)cycloalkyl-, aryl or aryloxy group, said groups being optionally substituted with one or more substituents chosen from a halogen atom or a (C1 -C6)alkoxy group; Z1 is absent or represents an -NH- function; Z2 and Z3 are as defined in the description. The invention also relates to a process for preparing compounds of formula (I), compositions containing them and their application in therapeutics.