319016-04-1Relevant articles and documents
Light-Promoted C–N Coupling of Aryl Halides with Nitroarenes
Li, Gang,Yang, Liu,Liu, Jian-Jun,Zhang, Wei,Cao, Rui,Wang, Chao,Zhang, Zunting,Xiao, Jianliang,Xue, Dong
supporting information, p. 5230 - 5234 (2021/02/05)
A photochemical C–N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a NiII complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald–Hartwig C–N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a NiI/NiIII cycle, to a nitrosoarene intermediate.
Heteroarylation method of amine
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Paragraph 0060-0070; 0076; 0078, (2021/02/24)
The invention discloses a heteroarylation method of amine, and the method comprises the following steps of: mixing an amine compound, heteroaromatic hydrocarbon, a photocatalyst and an organic solventto obtain a solution A; and in an inert gas atmosphere, irradiating the solution A with visible light, and carrying out reaction to obtain a heteroarylated product of amine. According to the method,under mild conditions, free radical coupling of amine compounds and heteroaromatic compounds is efficiently achieved through visible light irradiation, and various heteroarylamines are synthesized. The method has good functional group compatibility and high regioselectivity, can be further applied to later modification of bioactive molecules, and shows a good industrial application prospect.
Anti-1,2,2,3,4,4-hexamethylphosphetane 1-oxide
Nykaza, Trevor V.,Cooper, Julian C.,Radosevich, Alexander T.
, p. 418 - 435 (2019/11/21)
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